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Pou2af1 Gene Detail
Summary
  • Symbol
    Pou2af1
  • Name
    POU domain, class 2, associating factor 1
  • Synonyms
    Bob-1, Bob1, BOB.1, OBF-1, OBF.1, OCA-B, OCAB
  • Feature Type
    protein coding gene
  • IDs
    MGI:105086
    NCBI Gene: 18985
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:51125008-51151380 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 27.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    785 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105086
 protein coding gene Chr9:51124990-51151380 (+)
129S1/SvImJ ENSMUSG00200017970
 protein coding gene Chr9:48295778-48322595 (+)
A/J ENSMUSG00195020327
 protein coding gene Chr9:47986868-48013315 (+)
AKR/J ENSMUSG00220034171
 protein coding gene Chr9:48070178-48096563 (+)
BALB/cJ ENSMUSG00180030152
 protein coding gene Chr9:48098238-48124685 (+)
C3H/HeJ ENSMUSG00175015227
 protein coding gene Chr9:48110261-48136707 (+)
C57BL/6NJ ENSMUSG00215020421
 protein coding gene Chr9:48052482-48078870 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032204
 protein coding gene Chr9:48068303-48094573 (+)
CAST/EiJ ENSTCUG00005013887
 protein coding gene Chr9:48011665-48038212 (+)
CBA/J ENSMUSG00210015698
 protein coding gene Chr9:48175299-48201687 (+)
DBA/2J ENSMUSG00185010381
 protein coding gene Chr9:48224714-48251155 (+)
FVB/NJ ENSMUSG00205023430
 protein coding gene Chr9:48444810-48471248 (+)
JF1/MsJ ENSUMUG00000035529
 protein coding gene Chr9:48267347-48293996 (+)
LP/J ENSMUSG00230036019
 protein coding gene Chr9:48511546-48538347 (+)
NOD/ShiLtJ ENSMUSG00190020150
 protein coding gene Chr9:48304762-48331218 (+)
NZO/HlLtJ ENSMUSG00225043725
 protein coding gene Chr9:48480538-48506984 (+)
PWK/PhJ ENSLUMG00010020821
 protein coding gene Chr9:48237820-48264207 (+)
SPRET/EiJ ENSMSPG00010009958
 protein coding gene Chr9:49066000-49091900 (+)
WSB/EiJ ENSIUOG00005018818
 protein coding gene Chr9:47711913-47738359 (+)



Homology
more
  • Human Ortholog
    POU2AF1, POU class 2 homeobox associating factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU2AF1, POU class 2 homeobox associating factor 1
  • Synonyms
    BOB1, OBF-1, OBF1, OCAB
  • Links
    NCBI Gene ID: 5450
    UniProt: Q16633

  • Chr Location
    11q23.1; chr11:111352255-111455630 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 4 alleles in 5 genetic backgrounds
    21 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced numbers of mature B cells, absence of germinal centers, and low serum levels of non-IgM immunoglobulins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    198
  • cDNA Data
    36
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032053 Ensembl Gene Model | MGI Sequence Detail 26373 C57BL/6J ±  kb
    transcript ENSMUST00000034554 Ensembl | MGI Sequence Detail 2548 Not Applicable  
    polypeptide ENSMUSP00000034554 Ensembl | MGI Sequence Detail 256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      Genomic 2
      cDNA 36
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32126
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 52
    • Earliest
      J:29675 Yuan H, et al., Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 1995 Nov 1;9(21):2635-45
    • Latest
      J:385542 Zhu X, et al., Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 axis. Cell Rep. 2025 Oct 22;44(11):116470
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory