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Slc9a3 Gene Detail
Summary
  • Symbol
    Slc9a3
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 3
  • Synonyms
    9030624O13Rik, NHE-3, NHE3
  • Feature Type
    protein coding gene
  • IDs
    MGI:105064
    NCBI Gene: 105243
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:74269576-74317561 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 40.15 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1222 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105064
 protein coding gene Chr13:74234374-74317561 (+)
129S1/SvImJ ENSMUSG00200010972
 protein coding gene Chr13:68660787-68712126 (+)
A/J ENSMUSG00195028297
 protein coding gene Chr13:69248862-69300210 (+)
AKR/J ENSMUSG00220036657
 protein coding gene Chr13:67840394-67891749 (+)
BALB/cJ ENSMUSG00180021888
 protein coding gene Chr13:69747211-69798560 (+)
C3H/HeJ ENSMUSG00175007988
 protein coding gene Chr13:70025915-70077321 (+)
C57BL/6NJ ENSMUSG00215010526
 protein coding gene Chr13:69813189-69864537 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018716
 protein coding gene Chr13:68774932-68825369 (+)
CAST/EiJ ENSTCUG00005011476
 protein coding gene Chr13:69331045-69379410 (+)
CBA/J ENSMUSG00210008755
 protein coding gene Chr13:69348492-69399838 (+)
DBA/2J ENSMUSG00185017819
 protein coding gene Chr13:73040051-73091395 (+)
FVB/NJ ENSMUSG00205024540
 protein coding gene Chr13:68727414-68778761 (+)
JF1/MsJ ENSUMUG00000026396
 protein coding gene Chr13:72801687-72850052 (+)
LP/J ENSMUSG00230025459
 protein coding gene Chr13:82958750-83010097 (+)
NOD/ShiLtJ ENSMUSG00190029290
 protein coding gene Chr13:69347429-69398782 (+)
NZO/HlLtJ ENSMUSG00225027627
 protein coding gene Chr13:75465994-75517332 (+)
PWK/PhJ ENSLUMG00010010854
 protein coding gene Chr13:68842661-68894413 (+)
SPRET/EiJ ENSMSPG00010028911
 protein coding gene Chr13:69740470-69788467 (+)
WSB/EiJ ENSIUOG00005019588
 protein coding gene Chr13:68601267-68652622 (+)



Homology
more
  • Human Ortholog
    SLC9A3, solute carrier family 9 member A3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC9A3, solute carrier family 9 member A3
  • Synonyms
    DIAR8, NHE-3, NHE3
  • Links
    NCBI Gene ID: 6550
    UniProt: P48764

  • Chr Location
    5p15.33; chr5:470456-524449 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human SLC9A3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice have diarrhea associated with defects of renal and intestinal absorption. Males are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    677
  • Tissues
    64
  • cDNA Data
    6
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036123 Ensembl Gene Model | MGI Sequence Detail 47986 C57BL/6J ±  kb
    transcript ENSMUST00000225423 Ensembl | MGI Sequence Detail 2589 Not Applicable  
    polypeptide ENSMUSP00000153255 Ensembl | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 7
      Primer pair 3
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-32103, MGI:2145314
    References
    more
    • Summaries
      All 187
      Developmental Gene Expression 11
      Gene Ontology 11
      Phenotypes 74
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:391091 Isigibol Gezgin O, et al., Comparative analysis of acidosis defense mechanisms in preimplantation embryos in BALB/c strain mice: in vivo vs in vitro development. Reprod Fertil Dev. 2026 May 29;38(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory