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Dgkg Gene Detail
Summary
  • Symbol
    Dgkg
  • Name
    diacylglycerol kinase, gamma
  • Synonyms
    2900055E17Rik, Dagk3, E430001K23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:105060
    NCBI Gene: 110197
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22287211-22475971 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 13.37 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1172 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105060
 protein coding gene Chr16:22285318-22476051 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022670
 protein coding gene Chr16:19978352-20172120 (-)
A/J MGP_AJ_G0022631
 protein coding gene Chr16:19005639-19195759 (-)
AKR/J MGP_AKRJ_G0022606
 protein coding gene Chr16:19801132-19992621 (-)
BALB/cJ MGP_BALBcJ_G0022636
 protein coding gene Chr16:19201199-19392548 (-)
C3H/HeJ MGP_C3HHeJ_G0022400
 protein coding gene Chr16:19914834-20106294 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023086
 protein coding gene Chr16:20412511-20606936 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020604
 protein coding gene Chr16:19699636-19890064 (-)
CAST/EiJ MGP_CASTEiJ_G0021930
 protein coding gene Chr16:19896237-20101421 (-)
CBA/J MGP_CBAJ_G0022372
 protein coding gene Chr16:21274683-21478168 (-)
DBA/2J MGP_DBA2J_G0022504
 protein coding gene Chr16:18981362-19178070 (-)
FVB/NJ MGP_FVBNJ_G0022480
 protein coding gene Chr16:18951349-19144170 (-)
LP/J MGP_LPJ_G0022572
 protein coding gene Chr16:19728066-19925919 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022499
 protein coding gene Chr16:20828585-21028684 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023097
 protein coding gene Chr16:19760297-19951394 (-)
PWK/PhJ MGP_PWKPhJ_G0021670
 protein coding gene Chr16:19227022-19421540 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021500
 protein coding gene Chr16:19535093-19736007 (-)
WSB/EiJ MGP_WSBEiJ_G0021973
 protein coding gene Chr16:19711166-19907003 (-)



Homology
more
  • Human Ortholog
    DGKG, diacylglycerol kinase gamma
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGKG, diacylglycerol kinase gamma
  • Synonyms
    DAGK3, DGK-GAMMA
  • Links
    NCBI Gene ID: 1608
    neXtProt AC: NX_P49619
    UniProt: P49619

  • Chr Location
    3q27.2-q27.3; chr3:186105668-186362234 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout leads to neurological deficits, including impaired motor coordination and reduced stride length, owing to Purkinje cell dysmorphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    123
  • cDNA Data
    12
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022861 Ensembl Gene Model | MGI Sequence Detail 188761 C57BL/6J ±  kb
transcript ENSMUST00000089925 Ensembl | MGI Sequence Detail 3555 Not Applicable  
polypeptide ENSMUSP00000087371 Ensembl | MGI Sequence Detail 788 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000006446 diacylglycerol kinase gamma
    (term hierarchy)
  • EC
    2.7.1.107
  • InterPro Domains
    IPR046349 C1-like domain superfamily
    IPR038199 DGK type I, N-terminal domain superfamily
    IPR037607 Diacylglycerol kinase
    IPR000756 Diacylglycerol kinase, accessory domain
    IPR001206 Diacylglycerol kinase, catalytic domain
    IPR047475 Diacylglycerol kinase gamma, second protein kinase C conserved region 1
    IPR029477 Diacylglycerol kinase type I, N-terminal
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
    IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Molecular
Reagents
less
  • All nucleic 16
    cDNA 13
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-32099, MGI:1920250, MGI:2146514, MGI:2442219
References
more
  • Summaries
    All 56
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:25236 Pilz A, et al., Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene. Genomics. 1995 Apr 10;26(3):599-601
  • Latest
    J:305091 Tsumagari R, et al., Precise Regulation of the Basal PKCgamma Activity by DGKgamma Is Crucial for Motor Coordination. Int J Mol Sci. 2020 Oct 23;21(21):7866
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory