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Cyp2a12 Gene Detail
Summary
  • Symbol
    Cyp2a12
  • Name
    cytochrome P450, family 2, subfamily a, polypeptide 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:105055
    NCBI Gene: 13085
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:26728515-26736243 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105055
 protein coding gene Chr7:26728506-26736800 (+)
129S1/SvImJ ENSMUSG00200041074
 protein coding gene Chr7:16517734-16526445 (+)
A/J ENSMUSG00195048973
 protein coding gene Chr7:19164915-19174950 (+)
AKR/J ENSMUSG00220044783
 protein coding gene Chr7:25312454-25321070 (-)
BALB/cJ ENSMUSG00180052032
 protein coding gene Chr7:17230116-17240151 (+)
C3H/HeJ ENSMUSG00175049070
 protein coding gene Chr7:18286582-18295129 (+)
C57BL/6NJ ENSMUSG00215054633
 protein coding gene Chr7:16417569-16426116 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005047136
 protein coding gene Chr7:18214757-18222503 (+)
CBA/J ENSMUSG00210052450
 protein coding gene Chr7:17472093-17480640 (+)
DBA/2J ENSMUSG00185047967
 protein coding gene Chr7:20571758-20580457 (+)
FVB/NJ ENSMUSG00205043988
 protein coding gene Chr7:17261251-17269798 (+)
JF1/MsJ ENSUMUG00000044313
 protein coding gene Chr7:25000388-25009367 (+)
LP/J ENSMUSG00230052164
 protein coding gene Chr7:25743733-25752663 (+)
NOD/ShiLtJ ENSMUSG00190029449
 protein coding gene Chr7:16912498-16921457 (+)
NZO/HlLtJ ENSMUSG00225024089
 protein coding gene Chr7:24628147-24636694 (+)
PWK/PhJ ENSLUMG00010037151
 protein coding gene Chr7:16927651-16936574 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005053225
 protein coding gene Chr7:11161602-11170297 (+)



Homology
more
  • Human Ortholog
    CYP2A13, cytochrome P450 family 2 subfamily A member 13
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP2A13, cytochrome P450 family 2 subfamily A member 13
  • Synonyms
    CPAD, CYP2A, CYPIIA13
  • Links
    NCBI Gene ID: 1553
    UniProt: Q16696

  • Chr Location
    19q13.2; chr19:41088451-41096195 (+)  GRCh38
  • Human Ortholog
    CYP2A6, cytochrome P450 family 2 subfamily A member 6
  • Synonyms
    CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB
  • Links
    NCBI Gene ID: 1548
    UniProt: P11509

  • Chr Location
    19q13.2; chr19:40843533-40850450 (-)  GRCh38
  • Human Ortholog
    CYP2A7, cytochrome P450 family 2 subfamily A member 7
  • Synonyms
    CPA7, CPAD, CYP2A, CYPIIA7, P450-IIA4
  • Links
    NCBI Gene ID: 1549
    UniProt: P20853

  • Chr Location
    19q13.2; chr19:40875432-40882752 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CYP2A6 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    703
  • Tissues
    106
  • cDNA Data
    50
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13085 NCBI Gene Model | MGI Sequence Detail 7729 C57BL/6J ±  kb
transcript NM_133657 RefSeq | MGI Sequence Detail 1675 FVB/N  
polypeptide P56593 UniProt | EBI | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 50
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-32094
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:23304 Iwasaki M, et al., Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction. Biochem J. 1993 Apr 15;291(Pt 2):569-73
  • Latest
    J:386971 Tran LM, et al., Role of P450 enzymes of the Cyp2abfgs gene subfamilies in tobacco smoke-induced lung tumorigenesis in mice. Carcinogenesis. 2026 Mar 19;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory