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Mxd4 Gene Detail
Summary
  • Symbol
    Mxd4
  • Name
    Max dimerization protein 4
  • Synonyms
    2810410A03Rik, bHLHc12, Mad4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104991
    NCBI Gene: 17122
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:34331227-34345064 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 17.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104991
 protein coding gene Chr5:34331227-34345076 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029460
 protein coding gene Chr5:32382475-32397733 (-)
A/J MGP_AJ_G0029427
 protein coding gene Chr5:31328821-31343469 (-)
AKR/J MGP_AKRJ_G0029376
 protein coding gene Chr5:32535642-32549461 (-)
BALB/cJ MGP_BALBcJ_G0029437
 protein coding gene Chr5:31867867-31881686 (-)
C3H/HeJ MGP_C3HHeJ_G0029159
 protein coding gene Chr5:32576309-32590132 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029891
 protein coding gene Chr5:34274671-34289299 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027128
 protein coding gene Chr5:29105992-29119776 (-)
CAST/EiJ MGP_CASTEiJ_G0028568
 protein coding gene Chr5:31643889-31659449 (-)
CBA/J MGP_CBAJ_G0029127
 protein coding gene Chr5:35030099-35043955 (-)
DBA/2J MGP_DBA2J_G0029275
 protein coding gene Chr5:31502045-31515874 (-)
FVB/NJ MGP_FVBNJ_G0029234
 protein coding gene Chr5:30942497-30956514 (-)
LP/J MGP_LPJ_G0029360
 protein coding gene Chr5:32806020-32819833 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029264
 protein coding gene Chr5:35915653-35930902 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029924
 protein coding gene Chr5:32043935-32060531 (-)
PWK/PhJ MGP_PWKPhJ_G0028293
 protein coding gene Chr5:30639307-30653159 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028124
 protein coding gene Chr5:31492318-31506147 (-)
WSB/EiJ MGP_WSBEiJ_G0028649
 protein coding gene Chr5:32119797-32134089 (-)



Homology
more
  • Human Ortholog
    MXD4, MAX dimerization protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MXD4, MAX dimerization protein 4
  • Synonyms
    bHLHc12, MAD4, MST149, MSTP149
  • Links
    NCBI Gene ID: 10608
    neXtProt AC: NX_Q14582
    UniProt: Q14582

  • Chr Location
    4p16.3; chr4:2247432-2262109 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    801
  • Tissues
    38
  • cDNA Data
    14
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037235 Ensembl Gene Model | MGI Sequence Detail 13838 C57BL/6J ±  kb
    transcript ENSMUST00000042701 Ensembl | MGI Sequence Detail 3872 Not Applicable  
    polypeptide ENSMUSP00000039071 Ensembl | MGI Sequence Detail 209 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 1
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-31064, MGI:1916497
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 4
      Phenotypes 27
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:316178 Gamart J, et al., SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning. Development. 2021 Dec 1;148(23):dev200182
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory