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Gpc4 Gene Detail
Summary
  • Symbol
    Gpc4
  • Name
    glypican 4
  • Synonyms
    9530073D23Rik, K-glypican
  • Feature Type
    protein coding gene
  • IDs
    MGI:104902
    NCBI Gene: 14735
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:51141898-51254129 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 28.33 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104902
protein coding gene ChrX:51139884-51254129 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035715
protein coding gene ChrX:47250054-47366966 (-)
A/J MGP_AJ_G0035698
protein coding gene ChrX:47106298-47230274 (-)
AKR/J MGP_AKRJ_G0035618
protein coding gene ChrX:48404580-48521353 (-)
BALB/cJ MGP_BALBcJ_G0035684
protein coding gene ChrX:46658039-46770459 (-)
C3H/HeJ MGP_C3HHeJ_G0035388
protein coding gene ChrX:47499399-47614839 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036214
protein coding gene ChrX:48363969-48484076 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033065
protein coding gene ChrX:44580375-44692994 (-)
CAST/EiJ MGP_CASTEiJ_G0034679
protein coding gene ChrX:34944499-35062772 (-)
CBA/J MGP_CBAJ_G0035362
protein coding gene ChrX:49707924-49828918 (-)
DBA/2J MGP_DBA2J_G0035517
protein coding gene ChrX:46907829-47020770 (-)
FVB/NJ MGP_FVBNJ_G0035465
protein coding gene ChrX:46615139-46728051 (-)
LP/J MGP_LPJ_G0035604
protein coding gene ChrX:47558345-47676372 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035504
protein coding gene ChrX:51278320-51398145 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036231
protein coding gene ChrX:47129599-47243905 (-)
PWK/PhJ MGP_PWKPhJ_G0034378
protein coding gene ChrX:34433729-34548899 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034223
protein coding gene ChrX:35732284-35845353 (-)
WSB/EiJ MGP_WSBEiJ_G0034823
protein coding gene ChrX:46691677-46809116 (-)



Homology
more
  • Human Ortholog
    GPC4, glypican 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPC4, glypican 4
  • Synonyms
    K-glypican, KPTS
  • Links
    NCBI Gene ID: 2239
    neXtProt AC: NX_O75487
    UniProt: O75487

  • Chr Location
    Xq26.2; chrX:133300103-133415489 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human GPC4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a null allele exhibit signs of anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031119 Ensembl Gene Model | MGI Sequence Detail 112232 C57BL/6J ±  kb
    transcript ENSMUST00000033450 Ensembl | MGI Sequence Detail 2651 Not Applicable  
    polypeptide ENSMUSP00000033450 Ensembl | MGI Sequence Detail 557 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 23
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-29056, MGI:1925872, MGI:2147881, MGI:2147905, MGI:2152785
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 22
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:59268 Williams BO, et al., Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J. 1994 Sep 15;13(18):4251-9
    • Latest
      J:337768 Wishart TFL, et al., Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis. Cells. 2023 May 11;12(10)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory