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Ubp1 Gene Detail
Summary
  • Symbol
    Ubp1
  • Name
    upstream binding protein 1
  • Synonyms
    LBP-1a, LBP-1b, NF2d9
  • Feature Type
    protein coding gene
  • IDs
    MGI:104889
    NCBI Gene: 22221
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:113760002-113806270 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 64.14 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    869 from dbSNP Build 142
  • Strain Annotations
    24
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104889
 protein coding gene Chr9:113760002-113807095 (+)
129S1/SvImJ ENSMUSG00200043729
 protein coding gene Chr9:110896476-110898313 (+)
129S1/SvImJ ENSMUSG00200043541
 protein coding gene Chr9:110851349-110896859 (+)
A/J ENSMUSG00195033069
 protein coding gene Chr9:110220738-110222575 (+)
A/J ENSMUSG00195032978
 protein coding gene Chr9:110175576-110221121 (+)
AKR/J ENSMUSG00220022854
 protein coding gene Chr9:110551993-110553830 (+)
AKR/J ENSMUSG00220022807
 protein coding gene Chr9:110506820-110552376 (+)
BALB/cJ ENSMUSG00180026068
 protein coding gene Chr9:110595314-110640857 (+)
BALB/cJ ENSMUSG00180026226
 protein coding gene Chr9:110640474-110642311 (+)
C3H/HeJ ENSMUSG00175030862
 protein coding gene Chr9:110816378-110862647 (+)
C57BL/6NJ ENSMUSG00215038217
 protein coding gene Chr9:110705108-110751371 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032765
 protein coding gene Chr9:109139746-109186570 (+)
CAST/EiJ ENSTCUG00005026200
 protein coding gene Chr9:110508123-110553784 (+)
CBA/J ENSMUSG00210028595
 protein coding gene Chr9:110538338-110584622 (+)
DBA/2J ENSMUSG00185031366
 protein coding gene Chr9:110875379-110921658 (+)
FVB/NJ ENSMUSG00205048949
 protein coding gene Chr9:110842197-110844034 (+)
FVB/NJ ENSMUSG00205048882
 protein coding gene Chr9:110797042-110842580 (+)
JF1/MsJ ENSUMUG00000043544
 protein coding gene Chr9:110647508-110693266 (+)
LP/J ENSMUSG00230048007
 protein coding gene Chr9:110982438-111028673 (+)
NOD/ShiLtJ ENSMUSG00190049099
 protein coding gene Chr9:110468201-110514484 (+)
NZO/HlLtJ ENSMUSG00225023367
 protein coding gene Chr9:111263808-111310095 (+)
PWK/PhJ ENSLUMG00010033831
 protein coding gene Chr9:110658558-110704410 (+)
SPRET/EiJ ENSMSPG00010021594
 protein coding gene Chr9:112497518-112542915 (+)
WSB/EiJ ENSIUOG00005044547
 protein coding gene Chr9:109937554-109983938 (+)



Homology
more
  • Human Ortholog
    UBP1, upstream binding protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBP1, upstream binding protein 1
  • Synonyms
    LBP-1a, LBP1A, LBP-1B, LBP1B, TFCP2L5
  • Links
    NCBI Gene ID: 7342
    UniProt: Q9NZI7

  • Chr Location
    3p22.3; chr3:33388336-33441407 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die during gestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    170
  • cDNA Data
    19
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009741 Ensembl Gene Model | MGI Sequence Detail 46269 C57BL/6J ±  kb
    transcript ENSMUST00000084885 Ensembl | MGI Sequence Detail 3850 Not Applicable  
    polypeptide ENSMUSP00000081946 Ensembl | MGI Sequence Detail 540 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-29042
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 10
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:5178 Sanno Y, et al., Studies of a mutation affecting pyrimidine degradation in inbred mice. J Biol Chem. 1970 Nov 10;245(21):5668-76
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory