Ppp1cc MGI Mouse Gene Detail - MGI:104872 - protein phosphatase 1 catalytic subunit gamma

Symbol

Ppp1cc
Name

protein phosphatase 1 catalytic subunit gamma
Synonyms

PP1, PP1C gamma, PP1C gamma 1, PP1C gamma 2

Feature Type

protein coding gene
IDs

MGI:104872
NCBI Gene: 19047
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:122296341-122313336 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 62.20 cM, cytoband F-G1
Mapping Data

2 experiments

SNPs within 2kb

29 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104872	protein coding gene	Chr5:122296297-122313336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030043	protein coding gene	Chr5:125775266-125794436 (+)
A/J	MGP_AJ_G0030008	protein coding gene	Chr5:120575174-120594320 (+)
AKR/J	MGP_AKRJ_G0029944	protein coding gene	Chr5:124442198-124458947 (+)
BALB/cJ	MGP_BALBcJ_G0030019	protein coding gene	Chr5:121923210-121940841 (+)
C3H/HeJ	MGP_C3HHeJ_G0029736	protein coding gene	Chr5:125059708-125080002 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030472	protein coding gene	Chr5:130609301-130628453 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027698	protein coding gene	Chr5:115190641-115204862 (+)
CAST/EiJ	MGP_CASTEiJ_G0029145	protein coding gene	Chr5:124163288-124181972 (+)
CBA/J	MGP_CBAJ_G0029706	protein coding gene	Chr5:135728011-135744319 (+)
DBA/2J	MGP_DBA2J_G0029856	protein coding gene	Chr5:120629413-120647145 (+)
FVB/NJ	MGP_FVBNJ_G0029812	protein coding gene	Chr5:119607451-119626199 (+)
LP/J	MGP_LPJ_G0029945	protein coding gene	Chr5:126309993-126332625 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029843	protein coding gene	Chr5:139501038-139521372 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030513	protein coding gene	Chr5:124022577-124041576 (+)
PWK/PhJ	MGP_PWKPhJ_G0028859	protein coding gene	Chr5:119397502-119415896 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028696	protein coding gene	Chr5:121747243-121768229 (+)
WSB/EiJ	MGP_WSBEiJ_G0029220	protein coding gene	Chr5:124707731-124725266 (+)

Human Ortholog

PPP1CC, protein phosphatase 1 catalytic subunit gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1CC, protein phosphatase 1 catalytic subunit gamma
Synonyms

PP1C, PP-1G, PPP1G
Links

HGNC:9283

NCBI Gene ID: 5501

neXtProt AC: NX_P36873

UniProt: P36873
Chr Location

12q24.11; chr12:110708376-110742939 (-) GRCh38

MGI Vertebrate Homology

Ppp1cc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP1CC
Gene Tree

Ppp1cc

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Phenotype Summary

29 phenotypes from 4 alleles in 5 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

47
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

34
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Ppp1cc
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit male infertility due to severely impaired spermiogenesis.

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All GO Annotations

61
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

31
cDNA Data

21
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp1cc

ZFIN ppp1cc

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All Sequences

109
RefSeq

36
UniProt

8
CCDS

CCDS19643.1

Ensembl

ENSMUSG00000004455 (Evidence)
NCBI Gene

19047

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004455	Ensembl Gene Model \| MGI Sequence Detail	16996	C57BL/6J	± kb
transcript	ENSMUST00000086294	Ensembl \| MGI Sequence Detail	1442	Not Applicable
polypeptide	ENSMUSP00000083474	Ensembl \| MGI Sequence Detail	337	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000013104 serine/threonine-protein phosphatase PP1-gamma catalytic subunit

(term hierarchy)
PDB

4V0U, 4V0V, 4V0W, 4V0X
EC

3.1.3.16
InterPro Domains

IPR004843 Calcineurin-like phosphoesterase domain, ApaH type

IPR029052 Metallo-dependent phosphatase-like

IPR031675 Serine-threonine protein phosphatase, N-terminal

IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

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All nucleic 23

Genomic 2

cDNA 21

Microarray probesets 5

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MGD-MRK-28171

Summaries

All 105

Developmental Gene Expression 6

Gene Ontology 21

Phenotypes 37
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:342708 Gnan S, et al., Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction. Nat Commun. 2021 May 18;12(1):2910

TSS for Ppp1cc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48638	Chr5:122296328-122296403 (+)	25 bp
Tssr48639	Chr5:122306188-122306199 (+)	9,853 bp
Tssr48640	Chr5:122309570-122309591 (+)	13,240 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23