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Ier3 Gene Detail
Summary
  • Symbol
    Ier3
  • Name
    immediate early response 3
  • Synonyms
    cAMP inducible gene 3, cI-3, gly96, IEX-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104814
    NCBI Gene: 15937
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36132605-36133803 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104814
 protein coding gene Chr17:36132576-36133815 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023652
 protein coding gene Chr17:36015041-36016280 (+)
A/J MGP_AJ_G0023607
 protein coding gene Chr17:34900531-34901770 (+)
AKR/J MGP_AKRJ_G0023577
 protein coding gene Chr17:35327584-35328823 (+)
BALB/cJ MGP_BALBcJ_G0023612
 protein coding gene Chr17:35045548-35046787 (+)
C3H/HeJ MGP_C3HHeJ_G0023378
 protein coding gene Chr17:35792006-35793245 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024054
 protein coding gene Chr17:37487770-37489009 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021532
 protein coding gene Chr17:32597196-32598422 (+)
CAST/EiJ MGP_CASTEiJ_G0022869
 protein coding gene Chr17:35903953-35905192 (+)
CBA/J MGP_CBAJ_G0023356
 protein coding gene Chr17:39066693-39067932 (+)
DBA/2J MGP_DBA2J_G0023480
 protein coding gene Chr17:34207701-34208940 (+)
FVB/NJ MGP_FVBNJ_G0023451
 protein coding gene Chr17:34004201-34005440 (+)
LP/J MGP_LPJ_G0023560
 protein coding gene Chr17:36396400-36397639 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023472
 protein coding gene Chr17:37831413-37832652 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024097
 protein coding gene Chr17:35642557-35643796 (+)
PWK/PhJ MGP_PWKPhJ_G0022620
 protein coding gene Chr17:33068932-33070174 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022439
 protein coding gene Chr17:33689697-33690937 (+)
WSB/EiJ MGP_WSBEiJ_G0022935
 protein coding gene Chr17:35790602-35791845 (+)



Homology
more
  • Human Ortholog
    IER3, immediate early response 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IER3, immediate early response 3
  • Synonyms
    DIF2, DIF-2, GLY96, IEX1, IEX-1, IEX-1L, PRG1
  • Links
    NCBI Gene ID: 8870
    neXtProt AC: NX_P46695
    UniProt: P46695

  • Chr Location
    6p21.33; chr6:30743199-30744548 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IER3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations exhibit elevated systemic arterial pressure. Homozygotes for one null mutation also display cardiac hypertrophy. Homozygotes for a second null mutation display increased susceptibility to parasitic infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    123
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15937 NCBI Gene Model | MGI Sequence Detail 1199 C57BL/6J ±  kb
    transcript NM_133662 RefSeq | MGI Sequence Detail 1090 C57BL/6  
    polypeptide P46694 UniProt | EBI | MGI Sequence Detail 160 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 126
      Genomic 1
      cDNA 123
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28108, MGI:2146916
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:3978 Charles CH, et al., Genomic structure, cDNA sequence, and expression of gly96, a growth factor-inducible immediate-early gene encoding a short-lived glycosylated protein. Oncogene. 1993 Mar;8(3):797-801
    • Latest
      J:345604 Werren EA, et al., TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome. Nat Commun. 2024 Feb 22;15(1):1640
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory