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Nrcam Gene Detail
Summary
  • Symbol
    Nrcam
  • Name
    neuronal cell adhesion molecule
  • Synonyms
    Bravo, C030017F07Rik, C130076O07Rik, mKIAA0343
  • Feature Type
    protein coding gene
  • IDs
    MGI:104750
    NCBI Gene: 319504
  • Alliance
  • Transcription Start Sites
    19 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr12:44375668-44648747 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 20.71 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2890 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104750
protein coding gene Chr12:44375568-44651977 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019712
protein coding gene Chr12:42897852-43194603 (+)
A/J MGP_AJ_G0019676
protein coding gene Chr12:41364818-41641991 (+)
AKR/J MGP_AKRJ_G0019647
protein coding gene Chr12:42679935-42957377 (+)
BALB/cJ MGP_BALBcJ_G0019654
protein coding gene Chr12:41669875-41934175 (+)
C3H/HeJ MGP_C3HHeJ_G0019458
protein coding gene Chr12:42645353-42925465 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020101
protein coding gene Chr12:44158950-44447155 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017726
protein coding gene Chr12:40376406-40639562 (+)
CAST/EiJ MGP_CASTEiJ_G0019011
protein coding gene Chr12:37822159-38103938 (+)
CBA/J MGP_CBAJ_G0019430
protein coding gene Chr12:45630493-45923661 (+)
DBA/2J MGP_DBA2J_G0019543
protein coding gene Chr12:41250172-41519023 (+)
FVB/NJ MGP_FVBNJ_G0019532
protein coding gene Chr12:40777057-41040433 (+)
LP/J MGP_LPJ_G0019613
protein coding gene Chr12:42866511-43147053 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019568
protein coding gene Chr12:46328925-46630885 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020141
protein coding gene Chr12:42269163-42538380 (+)
PWK/PhJ MGP_PWKPhJ_G0018778
protein coding gene Chr12:35920666-36188161 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018568
protein coding gene Chr12:36868027-37146688 (+)
WSB/EiJ MGP_WSBEiJ_G0019061
protein coding gene Chr12:42580504-42858341 (+)



Homology
more
  • Human Ortholog
    NRCAM, neuronal cell adhesion molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRCAM, neuronal cell adhesion molecule
  • Synonyms
    NEDNMS
  • Links
    NCBI Gene ID: 4897
    neXtProt AC: NX_Q92823
    UniProt: Q92823

  • Chr Location
    7q31.1; chr7:108147623-108456720 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Nrcam mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 5 alleles in 8 genetic backgrounds
    38 phenotypes from multigenic genotypes
    4 images
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit disorganization of lens fibers, cellular disintegration, and accumulation of cellular debris resulting in cataracts. Mutants show mild reductions in cerebellar lobe size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020598 Ensembl Gene Model | MGI Sequence Detail 273080 C57BL/6J ±  kb
    transcript ENSMUST00000020939 Ensembl | MGI Sequence Detail 4469 Not Applicable  
    polypeptide ENSMUSP00000020939 Ensembl | MGI Sequence Detail 1256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 98
      Primer pair 6
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28041, MGI:1924717, MGI:2442157
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 41
      Diseases 1
      Gene Ontology 11
      Phenotypes 37
    • Earliest
      J:22422 Moscoso LM, et al., Expression of four immunoglobulin superfamily adhesion molecules (L1, Nr-CAM/Bravo, neurofascin/ABGP, and N-CAM) in the developing mouse spinal cord. J Comp Neurol. 1995 Feb 13;352(3):321-34
    • Latest
      J:336866 Puelles L, et al., The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. Int J Mol Sci. 2023 Jun 5;24(11)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory