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Adam4 Gene Detail
Summary
  • Symbol
    Adam4
  • Name
    a disintegrin and metallopeptidase domain 4
  • Synonyms
    tMDCV
  • Feature Type
    protein coding gene
  • IDs
    MGI:104731
    NCBI Gene: 11498
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:81466217-81468720 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 37.66 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104731
 protein coding gene Chr12:81466217-81468813 (-)
129S1/SvImJ ENSMUSG00200047305
 protein coding gene Chr12:73436465-73438968 (-)
A/J ENSMUSG00195028325
 protein coding gene Chr12:76130128-76132631 (-)
AKR/J ENSMUSG00220047948
 protein coding gene Chr12:73925488-73927991 (-)
BALB/cJ ENSMUSG00180020351
 protein coding gene Chr12:75100737-75103240 (-)
C3H/HeJ ENSMUSG00175037690
 protein coding gene Chr12:78262228-78264731 (-)
C57BL/6NJ ENSMUSG00215044327
 protein coding gene Chr12:74466260-74468763 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005028370
 protein coding gene Chr12:74393239-74395740 (-)
CBA/J ENSMUSG00210043612
 protein coding gene Chr12:74676457-74678960 (-)
DBA/2J ENSMUSG00185041192
 protein coding gene Chr12:76537266-76539769 (-)
FVB/NJ ENSMUSG00205026375
 protein coding gene Chr12:74276430-74278933 (-)
JF1/MsJ ENSUMUG00000013704
 protein coding gene Chr12:80527215-80529716 (-)
LP/J ENSMUSG00230042302
 protein coding gene Chr12:83554466-83556969 (-)
NOD/ShiLtJ ENSMUSG00190043303
 protein coding gene Chr12:73732058-73734561 (-)
NZO/HlLtJ ENSMUSG00225051956
 protein coding gene Chr12:85607962-85610465 (-)
PWK/PhJ ENSLUMG00010024257
 protein coding gene Chr12:74526886-74529387 (-)
SPRET/EiJ ENSMSPG00010016795
 protein coding gene Chr12:76365812-76368315 (-)
WSB/EiJ ENSIUOG00005042409
 protein coding gene Chr12:74348617-74351120 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    613
  • Tissues
    2
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000072972 Ensembl Gene Model | MGI Sequence Detail 2504 C57BL/6J ±  kb
transcript ENSMUST00000085319 Ensembl | MGI Sequence Detail 2504 Not Applicable  
polypeptide ENSMUSP00000082427 Ensembl | MGI Sequence Detail 763 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-27094, MGI:2144988
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory