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Rps6ka1 Gene Detail
Summary
  • Symbol
    Rps6ka1
  • Name
    ribosomal protein S6 kinase polypeptide 1
  • Synonyms
    Rsk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104558
    NCBI Gene: 20111
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133574601-133615108 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 66.37 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    488 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104558
protein coding gene Chr4:133574601-133615466 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028905
protein coding gene Chr4:136147837-136190777 (-)
A/J MGP_AJ_G0028864
protein coding gene Chr4:130429540-130469470 (-)
AKR/J MGP_AKRJ_G0028816
protein coding gene Chr4:134155925-134199631 (-)
BALB/cJ MGP_BALBcJ_G0028887
protein coding gene Chr4:131069055-131109408 (-)
C3H/HeJ MGP_C3HHeJ_G0028601
protein coding gene Chr4:134390917-134432368 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029329
protein coding gene Chr4:141040768-141089920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026600
protein coding gene Chr4:123496251-123538327 (-)
CAST/EiJ MGP_CASTEiJ_G0028034
protein coding gene Chr4:132514444-132557956 (-)
CBA/J MGP_CBAJ_G0028566
protein coding gene Chr4:144744012-144790819 (-)
DBA/2J MGP_DBA2J_G0028715
protein coding gene Chr4:130854223-130894600 (-)
FVB/NJ MGP_FVBNJ_G0028683
protein coding gene Chr4:129740718-129783704 (-)
LP/J MGP_LPJ_G0028816
protein coding gene Chr4:136243609-136286037 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028708
protein coding gene Chr4:149236793-149294735 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029367
protein coding gene Chr4:134589781-134630647 (-)
PWK/PhJ MGP_PWKPhJ_G0027754
protein coding gene Chr4:127571848-127613987 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027580
protein coding gene Chr4:130417209-130460131 (-)
WSB/EiJ MGP_WSBEiJ_G0028113
protein coding gene Chr4:134752582-134797916 (-)



Homology
more
  • Human Ortholog
    RPS6KA1, ribosomal protein S6 kinase A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS6KA1, ribosomal protein S6 kinase A1
  • Synonyms
    HU-1, MAPKAPK1, MAPKAPK1A, p90Rsk, RSK, RSK1
  • Links
    NCBI Gene ID: 6195
    neXtProt AC: NX_Q15418
    UniProt: Q15418

  • Chr Location
    1p36.11; chr1:26529761-26575030 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003644 Ensembl Gene Model | MGI Sequence Detail 40508 C57BL/6J ±  kb
transcript ENSMUST00000137486 Ensembl | MGI Sequence Detail 2296 Not Applicable  
polypeptide ENSMUSP00000119328 Ensembl | MGI Sequence Detail 741 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 140
    cDNA 138
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-25992
References
more
  • Summaries
    All 75
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 19
  • Earliest
    J:10010 Alcorta DA, et al., Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol. 1989 Sep;9(9):3850-9
  • Latest
    J:335072 Decourt C, et al., The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems. PLoS Biol. 2023 Apr;21(4):e3002044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory