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Rps6ka3 Gene Detail
Summary
  • Symbol
    Rps6ka3
  • Name
    ribosomal protein S6 kinase polypeptide 3
  • Synonyms
    Rsk2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104557
    NCBI Gene: 110651
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:158038652-158151240 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 73.27 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104557
 protein coding gene ChrX:157993303-158151240 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036223
 protein coding gene ChrX:157096152-157262901 (+)
A/J MGP_AJ_G0036193
 protein coding gene ChrX:156388420-156549948 (+)
AKR/J MGP_AKRJ_G0036121
 protein coding gene ChrX:161349607-161514572 (+)
BALB/cJ MGP_BALBcJ_G0036186
 protein coding gene ChrX:154469504-154623179 (+)
C3H/HeJ MGP_C3HHeJ_G0035892
 protein coding gene ChrX:157483415-157656510 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036708
 protein coding gene ChrX:161786549-161950957 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033530
 protein coding gene ChrX:147679187-147831630 (+)
CAST/EiJ MGP_CASTEiJ_G0035181
 protein coding gene ChrX:136533397-136698478 (+)
CBA/J MGP_CBAJ_G0035867
 protein coding gene ChrX:166443049-166559858 (+)
DBA/2J MGP_DBA2J_G0036033
 protein coding gene ChrX:155373880-155531954 (+)
FVB/NJ MGP_FVBNJ_G0035964
 protein coding gene ChrX:154542867-154653387 (+)
LP/J MGP_LPJ_G0036118
 protein coding gene ChrX:158267831-158428279 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035996
 protein coding gene ChrX:175061519-175256224 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036749
 protein coding gene ChrX:156643567-156808358 (+)
PWK/PhJ MGP_PWKPhJ_G0034879
 protein coding gene ChrX:133418529-133582096 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034700
 protein coding gene ChrX:136963227-137125902 (+)
WSB/EiJ MGP_WSBEiJ_G0035316
 protein coding gene ChrX:154613921-154774055 (+)



Homology
more
  • Human Ortholog
    RPS6KA3, ribosomal protein S6 kinase A3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS6KA3, ribosomal protein S6 kinase A3
  • Synonyms
    CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, p90-RSK2, pp90RSK2, RSK, RSK2, S6K-alpha3, XLID19
  • Links
    NCBI Gene ID: 6197
    neXtProt AC: NX_P51812
    UniProt: P51812

  • Chr Location
    Xp22.12; chrX:20149911-20267519 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rps6ka3 mouse models; 3 with human RPS6KA3 associations

Human Disease Mouse Models
      
IDs
 View 5 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes/hemizygotes are a model for Coffin-Lowry Syndrome. One allele shows impaired osteoblast function with reduced long and craniofacial bones. Another allele shows infertility, lipodystrophy, impaired glycogen, glucose, and insulin metabolism, and impaired memory and coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    803
  • Tissues
    73
  • cDNA Data
    18
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110651 NCBI Gene Model | MGI Sequence Detail 112589 C57BL/6J ±  kb
    transcript NM_001346675 RefSeq | MGI Sequence Detail 7451 ZRU/MplStud  
    polypeptide P18654 UniProt | EBI | MGI Sequence Detail 740 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 19
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-25991
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 10
      Diseases 5
      Gene Ontology 11
      Phenotypes 37
    • Earliest
      J:10010 Alcorta DA, et al., Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Mol Cell Biol. 1989 Sep;9(9):3850-9
    • Latest
      J:341375 Kalra J, et al., p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle. Front Physiol. 2023;14:1228488
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory