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Prg2 Gene Detail
Summary
  • Symbol
    Prg2
  • Name
    proteoglycan 2, bone marrow
  • Synonyms
    EMBP, mMBP, mMBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103294
    NCBI Gene: 19074
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84810805-84813976 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103294
 protein coding gene Chr2:84810805-84813977 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025917
 protein coding gene Chr2:85686621-85689790 (+)
A/J MGP_AJ_G0025891
 protein coding gene Chr2:82365239-82368420 (+)
AKR/J MGP_AKRJ_G0025861
 protein coding gene Chr2:84496080-84499263 (+)
BALB/cJ MGP_BALBcJ_G0025888
 protein coding gene Chr2:82495783-82498964 (+)
C3H/HeJ MGP_C3HHeJ_G0025647
 protein coding gene Chr2:84727209-84730392 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026334
 protein coding gene Chr2:88341024-88344195 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023736
 protein coding gene Chr2:79192406-79195597 (+)
CAST/EiJ MGP_CASTEiJ_G0025108
 protein coding gene Chr2:85274125-85277274 (+)
CBA/J MGP_CBAJ_G0025628
 protein coding gene Chr2:91492301-91495480 (+)
DBA/2J MGP_DBA2J_G0025759
 protein coding gene Chr2:81902299-81905478 (+)
FVB/NJ MGP_FVBNJ_G0025722
 protein coding gene Chr2:81157115-81160274 (+)
LP/J MGP_LPJ_G0025847
 protein coding gene Chr2:85476786-85479967 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025752
 protein coding gene Chr2:93813127-93816296 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026390
 protein coding gene Chr2:84744044-84747223 (+)
PWK/PhJ MGP_PWKPhJ_G0024852
 protein coding gene Chr2:81744881-81749274 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024656
 protein coding gene Chr2:84864151-84867325 (+)
WSB/EiJ MGP_WSBEiJ_G0025178
 protein coding gene Chr2:85399355-85403981 (+)



Homology
more
  • Human Ortholog
    PRG2, proteoglycan 2, pro eosinophil major basic protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRG2, proteoglycan 2, pro eosinophil major basic protein
  • Synonyms
    BMPG, MBP, MBP1, proMBP
  • Links
    NCBI Gene ID: 5553
    neXtProt AC: NX_P13727
    UniProt: P13727

  • Chr Location
    11q12.1; chr11:57386780-57390650 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype although fine structure changes occur in eosinophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    17
  • cDNA Data
    6
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027073 Ensembl Gene Model | MGI Sequence Detail 3172 C57BL/6J ±  kb
    transcript ENSMUST00000028467 Ensembl | MGI Sequence Detail 838 Not Applicable  
    polypeptide ENSMUSP00000028467 Ensembl | MGI Sequence Detail 223 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 9
      cDNA 6
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24176
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:28584 Larson KA, et al., The identification and cloning of a murine major basic protein gene expressed in eosinophils. J Immunol. 1995 Sep 15;155(6):3002-12
    • Latest
      J:318598 Lu Y, et al., Eosinophil extracellular traps drive asthma progression through neuro-immune signals. Nat Cell Biol. 2021 Oct;23(10):1060-1072
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory