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Eif4ebp1 Gene Detail
Summary
  • Symbol
    Eif4ebp1
  • Name
    eukaryotic translation initiation factor 4E binding protein 1
  • Synonyms
    4e-bp1, PHAS-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:103267
    NCBI Gene: 13685
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:27750355-27765684 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 15.95 cM, cytoband A4-B1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103267
 protein coding gene Chr8:27750355-27766702 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033506
 protein coding gene Chr8:25457571-25475381 (+)
A/J MGP_AJ_G0033486
 protein coding gene Chr8:24482136-24497916 (+)
AKR/J MGP_AKRJ_G0033411
 protein coding gene Chr8:25308655-25324024 (+)
BALB/cJ MGP_BALBcJ_G0033482
 protein coding gene Chr8:24650955-24667054 (+)
C3H/HeJ MGP_C3HHeJ_G0033196
 protein coding gene Chr8:25512947-25528353 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033998
 protein coding gene Chr8:26431757-26448223 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030948
 protein coding gene Chr8:21735681-21752250 (+)
CAST/EiJ MGP_CASTEiJ_G0032522
 protein coding gene Chr8:25012346-25027780 (+)
CBA/J MGP_CBAJ_G0033171
 protein coding gene Chr8:27484797-27503079 (+)
DBA/2J MGP_DBA2J_G0033326
 protein coding gene Chr8:24452502-24468282 (+)
FVB/NJ MGP_FVBNJ_G0033270
 protein coding gene Chr8:24261852-24277127 (+)
LP/J MGP_LPJ_G0033415
 protein coding gene Chr8:25412786-25429792 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033313
 protein coding gene Chr8:26919452-26934947 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034017
 protein coding gene Chr8:25282368-25297721 (+)
PWK/PhJ MGP_PWKPhJ_G0032233
 protein coding gene Chr8:24114819-24131920 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032067
 protein coding gene Chr8:24656523-24671802 (+)
WSB/EiJ MGP_WSBEiJ_G0032638
 protein coding gene Chr8:25463638-25480130 (+)



Homology
more
  • Human Ortholog
    EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4EBP1, eukaryotic translation initiation factor 4E binding protein 1
  • Synonyms
    4EBP1, 4E-BP1, BP-1, PHAS-I
  • Links
    NCBI Gene ID: 1978
    neXtProt AC: NX_Q13541
    UniProt: Q13541

  • Chr Location
    8p11.23; chr8:38030534-38060365 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted mutation display hypoglycemia and hypoleptinemia with significantly reduced white fat pads and a notable increase in metabolic rate. Male white adipose tissue exhibits the multilocular appearance of brown adipocytes, and expresses UCP1, a specific marker of brown fat.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    831
  • Tissues
    53
  • cDNA Data
    91
  • Literature Summary
    56
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13685 NCBI Gene Model | MGI Sequence Detail 15330 C57BL/6J ±  kb
    transcript NM_007918 RefSeq | MGI Sequence Detail 981 ZRU/MplStud  
    polypeptide Q60876 UniProt | EBI | MGI Sequence Detail 117 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000006994 eukaryotic translation initiation factor 4E-binding protein 1
      (term hierarchy)
    • InterPro Domains
      IPR008606 Eukaryotic translation initiation factor 4E binding
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 1
      cDNA 91

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-24146, MGI:2142450
    References
    more
    • Summaries
      All 171
      Developmental Gene Expression 56
      Gene Ontology 11
      Phenotypes 57
    • Earliest
      J:27764 Lin TA, et al., Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J Biol Chem. 1995 Aug 4;270(31):18531-8
    • Latest
      J:342544 Radzishevsky I, et al., Impairment of serine transport across the blood-brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction. Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2302780120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory