About   Help   FAQ
Epb41l5 Gene Detail
Summary
  • Symbol
    Epb41l5
  • Name
    erythrocyte membrane protein band 4.1 like 5
  • Synonyms
    1700030C16Rik, E230025E14Rik, Epb4.1l5, Lulu1, NBL5
  • Feature Type
    protein coding gene
  • IDs
    MGI:103006
    NCBI Gene: 226352
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:119472767-119576730 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    318 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103006
 protein coding gene Chr1:119472762-119576826 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016397
 protein coding gene Chr1:122297517-122407128 (-)
A/J MGP_AJ_G0016380
 protein coding gene Chr1:117915639-118020698 (-)
AKR/J MGP_AKRJ_G0016345
 protein coding gene Chr1:121395667-121507996 (-)
BALB/cJ MGP_BALBcJ_G0016340
 protein coding gene Chr1:118180560-118285085 (-)
C3H/HeJ MGP_C3HHeJ_G0016166
 protein coding gene Chr1:121568879-121673928 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016801
 protein coding gene Chr1:126986440-127091350 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014514
 protein coding gene Chr1:111582167-111682225 (-)
CAST/EiJ MGP_CASTEiJ_G0015747
 protein coding gene Chr1:120338262-120445030 (-)
CBA/J MGP_CBAJ_G0016139
 protein coding gene Chr1:131356267-131467740 (-)
DBA/2J MGP_DBA2J_G0016245
 protein coding gene Chr1:116935855-117041279 (-)
FVB/NJ MGP_FVBNJ_G0016244
 protein coding gene Chr1:115679383-115789519 (-)
LP/J MGP_LPJ_G0016316
 protein coding gene Chr1:123634527-123744479 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016269
 protein coding gene Chr1:137077684-137186106 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016837
 protein coding gene Chr1:121102803-121210381 (-)
PWK/PhJ MGP_PWKPhJ_G0015533
 protein coding gene Chr1:115928020-116029097 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015321
 protein coding gene Chr1:120001306-120114657 (-)
WSB/EiJ MGP_WSBEiJ_G0015809
 protein coding gene Chr1:120988969-121092918 (-)



Homology
more
  • Human Ortholog
    EPB41L5, erythrocyte membrane protein band 4.1 like 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPB41L5, erythrocyte membrane protein band 4.1 like 5
  • Synonyms
    BE37, LULU, LULU1, YMO1, YRT
  • Links
    NCBI Gene ID: 57669
    neXtProt AC: NX_Q9HCM4
    UniProt: Q9HCM4

  • Chr Location
    2q14.2; chr2:120013077-120179119 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 5 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a number of different mutations exhibit prenatal lethality and mesodermal and epithelial-mesenchymal transition defects during gastrulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    759
  • Tissues
    23
  • cDNA Data
    25
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026383 Ensembl Gene Model | MGI Sequence Detail 103964 C57BL/6J ±  kb
    transcript ENSMUST00000163147 Ensembl | MGI Sequence Detail 3370 Not Applicable  
    polypeptide ENSMUSP00000128374 Ensembl | MGI Sequence Detail 739 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 26

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-23843, MGI:1922900, MGI:2138387, MGI:2445067
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:312325 Maier JI, et al., EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission. Cell Rep. 2021 Mar 23;34(12):108883
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory