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Ptprm Gene Detail
Summary
  • Symbol
    Ptprm
  • Name
    protein tyrosine phosphatase receptor type M
  • Synonyms
    RPTPmu
  • Feature Type
    protein coding gene
  • IDs
    MGI:102694
    NCBI Gene: 19274
  • Alliance
    genome feature page
  • Transcription Start Sites
    25 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:66973942-67661452 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 37.88 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21989 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102694
 protein coding gene Chr17:66973843-67661486 (-)
129S1/SvImJ ENSMUSG00200037586
 protein coding gene Chr17:62314573-63011046 (-)
A/J ENSMUSG00195015811
 protein coding gene Chr17:63656881-64353417 (-)
AKR/J ENSMUSG00220017895
 protein coding gene Chr17:62737604-63425870 (-)
BALB/cJ ENSMUSG00180016942
 protein coding gene Chr17:63394191-64090735 (-)
C3H/HeJ ENSMUSG00175028811
 protein coding gene Chr17:62701722-63398171 (-)
C57BL/6NJ ENSMUSG00215024068
 protein coding gene Chr17:62362495-63050763 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021841
 protein coding gene Chr17:62791050-63473151 (-)
CAST/EiJ ENSTCUG00005025483
 protein coding gene Chr17:63307674-63988325 (-)
CBA/J ENSMUSG00210029918
 protein coding gene Chr17:62501637-63198016 (-)
DBA/2J ENSMUSG00185021820
 protein coding gene Chr17:65346095-66042571 (-)
FVB/NJ ENSMUSG00205012297
 protein coding gene Chr17:63120699-63819768 (-)
JF1/MsJ ENSUMUG00000026708
 protein coding gene Chr17:65011699-65704817 (-)
LP/J ENSMUSG00230016529
 protein coding gene Chr17:66332812-67029239 (-)
NOD/ShiLtJ ENSMUSG00190035139
 protein coding gene Chr17:62480548-63176992 (-)
NZO/HlLtJ ENSMUSG00225025851
 protein coding gene Chr17:68609481-69305167 (-)
PWK/PhJ ENSLUMG00010026202
 protein coding gene Chr17:62297164-62983123 (-)
SPRET/EiJ ENSMSPG00010015269
 protein coding gene Chr17:62648715-63350260 (-)
WSB/EiJ ENSIUOG00005031418
 protein coding gene Chr17:63352667-64049454 (-)



Homology
more
  • Human Ortholog
    PTPRM, protein tyrosine phosphatase receptor type M
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRM, protein tyrosine phosphatase receptor type M
  • Synonyms
    hR-PTPu, PTPRL1, RPTPM, R-PTP-MU, RPTPU
  • Links
    NCBI Gene ID: 5797
    UniProt: P28827

  • Chr Location
    18p11.23; chr18:7566782-8406861 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired flow-induced dilation in mesenteric resistance arteries.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1164
  • Tissues
    226
  • cDNA Data
    50
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033278 Ensembl Gene Model | MGI Sequence Detail 687511 C57BL/6J ±  kb
    transcript ENSMUST00000037974 Ensembl | MGI Sequence Detail 5186 Not Applicable  
    polypeptide ENSMUSP00000045603 Ensembl | MGI Sequence Detail 1486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000013473 receptor-type tyrosine-protein phosphatase mu
      (term hierarchy)
    • EC
      3.1.3.48
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR003599 Immunoglobulin domain subtype
      IPR013151 Immunoglobulin-like beta-sandwich domain
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR000998 MAM domain
      IPR050348 Protein-Tyrosine Phosphatase
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR003595 Protein-tyrosine phosphatase, catalytic
      IPR029021 Protein-tyrosine phosphatase-like
      IPR045911 Receptor-type tyrosine-protein phosphatase mu, PTPase domain, repeat 1
      IPR057598 Receptor-type tyrosine-protein phosphatase U-like, Fn3 domain
      IPR051622 Type IIB receptor protein tyrosine phosphatase
      IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
      IPR000387 Tyrosine-specific protein phosphatases domain
    • GlyGen
      P28828 13 sites, 9 N-linked glycans (10 sites)
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 53
      Primer pair 3
      Other 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19598
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 14
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:14621 Gebbink MF, et al., Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase. FEBS Lett. 1991 Sep 23;290(1-2):123-30
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory