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Pou3f3 Gene Detail
Summary
  • Symbol
    Pou3f3
  • Name
    POU domain, class 3, transcription factor 3
  • Synonyms
    Brn1, Brn-1, HST011, Otf8, urehr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102564
    NCBI Gene: 18993
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:42734928-42739370 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 21.21 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102564
 protein coding gene Chr1:42734085-42742336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015974
 protein coding gene Chr1:41644666-41653404 (+)
A/J MGP_AJ_G0015958
 protein coding gene Chr1:40409808-40417360 (+)
AKR/J MGP_AKRJ_G0015913
 protein coding gene Chr1:40921295-40928680 (+)
BALB/cJ MGP_BALBcJ_G0015912
 protein coding gene Chr1:40068554-40076208 (+)
C3H/HeJ MGP_C3HHeJ_G0015745
 protein coding gene Chr1:41300442-41308493 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016365
 protein coding gene Chr1:43367639-43376020 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014087
 protein coding gene Chr1:37236641-37244086 (+)
CAST/EiJ MGP_CASTEiJ_G0015326
 protein coding gene Chr1:41280476-41288644 (+)
CBA/J MGP_CBAJ_G0015717
 protein coding gene Chr1:44640242-44653515 (+)
DBA/2J MGP_DBA2J_G0015818
 protein coding gene Chr1:39675989-39683785 (+)
FVB/NJ MGP_FVBNJ_G0015820
 protein coding gene Chr1:39206861-39214059 (+)
LP/J MGP_LPJ_G0015888
 protein coding gene Chr1:41987395-41994273 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015840
 protein coding gene Chr1:46622640-46630617 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016412
 protein coding gene Chr1:41124696-41135277 (+)
PWK/PhJ MGP_PWKPhJ_G0015109
 protein coding gene Chr1:39539369-39547551 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014891
 protein coding gene Chr1:41124317-41132718 (+)
WSB/EiJ MGP_WSBEiJ_G0015388
 protein coding gene Chr1:41164289-41174777 (+)



Homology
more
  • Human Ortholog
    POU3F3, POU class 3 homeobox 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU3F3, POU class 3 homeobox 3
  • Synonyms
    brain-1, BRN1, oct-8, OTF8, SNIBFIS
  • Links
    NCBI Gene ID: 5455
    neXtProt AC: NX_P20264
    UniProt: P20264

  • Chr Location
    2q12.1; chr2:104853287-104858574 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in death within 36 hours after birth. Mutant brains exhibit disorganized cells in the hippocampus and adjacent transitional cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1384
  • Tissues
    307
  • cDNA Data
    10
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18993 NCBI Gene Model | MGI Sequence Detail 4443 C57BL/6J ±  kb
    transcript NM_008900 RefSeq | MGI Sequence Detail 4443 ZRU/MplStud  
    polypeptide P31361 UniProt | EBI | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 14
      Primer pair 5
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13083, MGD-MRK-1623, MGD-MRK-1627, MGD-MRK-19445, MGI:3712270
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 109
      Gene Ontology 13
      Phenotypes 12
    • Earliest
      J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
    • Latest
      J:341383 Salamon I, et al., Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Nat Commun. 2023 Sep 27;14(1):6025
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory