About   Help   FAQ
Hnrnpd Gene Detail
Summary
  • Symbol
    Hnrnpd
  • Name
    heterogeneous nuclear ribonucleoprotein D
  • Synonyms
    Auf1, Hnrpd
  • Feature Type
    protein coding gene
  • IDs
    MGI:101947
    NCBI Gene: 11991
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:100103794-100126797 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 48.46 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101947
protein coding gene Chr5:100103794-100126926 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029780
protein coding gene Chr5:101404520-101427356 (-)
A/J MGP_AJ_G0029746
protein coding gene Chr5:97633058-97660422 (-)
AKR/J MGP_AKRJ_G0029692
protein coding gene Chr5:100871949-100894838 (-)
BALB/cJ MGP_BALBcJ_G0029756
protein coding gene Chr5:98656957-98683194 (-)
C3H/HeJ MGP_C3HHeJ_G0029479
protein coding gene Chr5:101200368-101224598 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030211
protein coding gene Chr5:105647335-105670251 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027446
protein coding gene Chr5:92900799-92924226 (-)
CAST/EiJ MGP_CASTEiJ_G0028890
protein coding gene Chr5:99838912-99863276 (-)
CBA/J MGP_CBAJ_G0029449
protein coding gene Chr5:109282167-109305206 (-)
DBA/2J MGP_DBA2J_G0029593
protein coding gene Chr5:97827536-97853681 (-)
FVB/NJ MGP_FVBNJ_G0029552
protein coding gene Chr5:96636021-96659003 (-)
LP/J MGP_LPJ_G0029681
protein coding gene Chr5:102005026-102028658 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029581
protein coding gene Chr5:114374175-114399608 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030244
protein coding gene Chr5:100337897-100361940 (-)
PWK/PhJ MGP_PWKPhJ_G0028608
protein coding gene Chr5:96269127-96292479 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028443
protein coding gene Chr5:98017470-98040336 (-)
WSB/EiJ MGP_WSBEiJ_G0028968
protein coding gene Chr5:100652683-100675519 (-)



Homology
more
  • Human Ortholog
    HNRNPD, heterogeneous nuclear ribonucleoprotein D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPD, heterogeneous nuclear ribonucleoprotein D
  • Synonyms
    AUF1, AUF1A, hnRNPD0, HNRPD, P37
  • Links
    NCBI Gene ID: 3184
    neXtProt AC: NX_Q14103
    UniProt: Q14103

  • Chr Location
    4q21.22; chr4:82352498-82374503 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in fetal growth retardation and decreased body weight. Mice show increased susceptibility to bacterial infection and endotoxin shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000568 Ensembl Gene Model | MGI Sequence Detail 23004 C57BL/6J ±  kb
    transcript ENSMUST00000172361 Ensembl | MGI Sequence Detail 6811 Not Applicable  
    polypeptide ENSMUSP00000132735 Ensembl | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 181
      cDNA 175
      Primer pair 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18781
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:343100 Takada Y, et al., Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development. Sci Adv. 2023 Nov 24;9(47):eadg6532

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory