About   Help   FAQ
Plk4 Gene Detail
Summary
  • Symbol
    Plk4
  • Name
    polo like kinase 4
  • Synonyms
    Sak, Stk18
  • Feature Type
    protein coding gene
  • IDs
    MGI:101783
    NCBI Gene: 20873
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:40754463-40771318 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 19.54 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    415 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101783
 protein coding gene Chr3:40754454-40771318 (+)
129S1/SvImJ ENSMUSG00200005734
 protein coding gene Chr3:37498054-37514922 (+)
A/J ENSMUSG00195001390
 protein coding gene Chr3:37482447-37499305 (+)
AKR/J ENSMUSG00220000360
 protein coding gene Chr3:37564295-37581164 (+)
BALB/cJ ENSMUSG00180002287
 protein coding gene Chr3:37609555-37626413 (+)
C3H/HeJ ENSMUSG00175003112
 protein coding gene Chr3:37480329-37497183 (+)
C57BL/6NJ ENSMUSG00215001482
 protein coding gene Chr3:37892037-37908903 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024959
 protein coding gene Chr3:35387539-35404112 (+)
CAST/EiJ ENSTCUG00005000898
 protein coding gene Chr3:37341648-37358305 (+)
CBA/J ENSMUSG00210001126
 protein coding gene Chr3:37575750-37592604 (+)
DBA/2J ENSMUSG00185001118
 protein coding gene Chr3:37772332-37789191 (+)
FVB/NJ ENSMUSG00205000466
 protein coding gene Chr3:36891747-36908384 (+)
JF1/MsJ ENSUMUG00000000492
 protein coding gene Chr3:37267101-37283715 (+)
LP/J ENSMUSG00230020976
 protein coding gene Chr3:39739041-39755907 (+)
NOD/ShiLtJ ENSMUSG00190001115
 protein coding gene Chr3:37829576-37846442 (+)
NZO/HlLtJ ENSMUSG00225000413
 protein coding gene Chr3:42359976-42376842 (+)
PWK/PhJ ENSLUMG00010000629
 protein coding gene Chr3:37310894-37327755 (+)
SPRET/EiJ ENSMSPG00010000546
 protein coding gene Chr3:37782638-37799252 (+)
WSB/EiJ ENSIUOG00005013375
 protein coding gene Chr3:37748742-37765390 (+)



Homology
more
  • Human Ortholog
    PLK4, polo like kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLK4, polo like kinase 4
  • Synonyms
    MCCRP2, SAK, STK18
  • Links
    NCBI Gene ID: 10733
    UniProt: O00444

  • Chr Location
    4q28.1; chr4:127880890-127899224 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLK4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene die before birth. Development is arrested around E7.5. Mice heterozygous for an ENU-induced allele or gene trap alele exhibit male hypogonadism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    53
  • cDNA Data
    82
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20873 NCBI Gene Model | MGI Sequence Detail 16856 C57BL/6J ±  kb
    transcript NM_011495 RefSeq | MGI Sequence Detail 3470 C57BL/6  
    polypeptide Q64702 UniProt | EBI | MGI Sequence Detail 925 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 82
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-18591, MGI:2139687
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 15
      Phenotypes 32
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:363363 Skinner MW, et al., Spermatocytes have the capacity to segregate chromosomes despite centriole duplication failure. EMBO Rep. 2024 Jun 28;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory