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Htr1f Gene Detail
Summary
  • Symbol
    Htr1f
  • Name
    5-hydroxytryptamine (serotonin) receptor 1F
  • Synonyms
    Htr1eb
  • Feature Type
    protein coding gene
  • IDs
    MGI:99842
    NCBI Gene: 15557
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:64745092-64926147 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 37.10 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4066 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99842
 protein coding gene Chr16:64745092-64926217 (-)
129S1/SvImJ ENSMUSG00200008098
 protein coding gene Chr16:61721440-61902091 (-)
A/J ENSMUSG00195001583
 protein coding gene Chr16:61362829-61538596 (-)
AKR/J ENSMUSG00220005481
 protein coding gene Chr16:61643939-61825883 (-)
BALB/cJ ENSMUSG00180001608
 protein coding gene Chr16:61491450-61665861 (-)
C3H/HeJ ENSMUSG00175004409
 protein coding gene Chr16:61771357-61952064 (-)
C57BL/6NJ ENSMUSG00215012362
 protein coding gene Chr16:61584957-61766159 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020864
 protein coding gene Chr16:60730310-60872964 (-)
CAST/EiJ ENSTCUG00005012535
 protein coding gene Chr16:61643540-61799534 (-)
CBA/J ENSMUSG00210015107
 protein coding gene Chr16:61722380-61896791 (-)
DBA/2J ENSMUSG00185004492
 protein coding gene Chr16:61668760-61843175 (-)
FVB/NJ ENSMUSG00205011219
 protein coding gene Chr16:61462361-61646677 (-)
JF1/MsJ ENSUMUG00000014986
 protein coding gene Chr16:61774776-61938627 (-)
LP/J ENSMUSG00230006711
 protein coding gene Chr16:64223239-64404389 (-)
NOD/ShiLtJ ENSMUSG00190015898
 protein coding gene Chr16:61719770-61900975 (-)
NZO/HlLtJ ENSMUSG00225035669
 protein coding gene Chr16:67460720-67641893 (-)
PWK/PhJ ENSLUMG00010011452
 protein coding gene Chr16:61482409-61644123 (-)
SPRET/EiJ ENSMSPG00010002035
 protein coding gene Chr16:62215716-62375759 (-)
WSB/EiJ ENSIUOG00005002302
 protein coding gene Chr16:61771607-61945929 (-)



Homology
more
  • Human Ortholog
    HTR1F, 5-hydroxytryptamine receptor 1F
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR1F, 5-hydroxytryptamine receptor 1F
  • Synonyms
    5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77
  • Links
    NCBI Gene ID: 3355
    UniProt: P30939

  • Chr Location
    3p11.2-p11.1; chr3:87792704-87993839 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display decreased temperature sensitivity and physiological abnormalities in nerve fibers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1003
  • Tissues
    170
  • cDNA Data
    7
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15557 NCBI Gene Model | MGI Sequence Detail 181056 C57BL/6J ±  kb
    transcript NM_008310 RefSeq | MGI Sequence Detail 2509 ZRU/MplStud  
    polypeptide Q02284 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 8
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11006, MGD-MRK-16633, MGI:96280
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:2640 Amlaiky N, et al., Isolation of a mouse 5HT1E-like serotonin receptor expressed predominantly in hippocampus. J Biol Chem. 1992 Oct 5;267(28):19761-4
    • Latest
      J:386338 Thompson AD, et al., 5-Hydroxytryptamine 1F receptor loss reduces renal vasculature and prevents lasmiditan-induced recovery following moderate-severe acute kidney injury in mice. Am J Physiol Renal Physiol. 2025 Dec 1;329(6):F834-F852
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory