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Septin2 Gene Detail
Summary
  • Symbol
    Septin2
  • Name
    septin 2
  • Synonyms
    mKIAA0158, Nedd5, Sept2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97298
    NCBI Gene: 18000
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93406671-93437455 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97298
 protein coding gene Chr1:93406671-93437982 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016343
 protein coding gene Chr1:95104869-95137109 (+)
A/J MGP_AJ_G0016324
 protein coding gene Chr1:91697044-91726797 (+)
AKR/J MGP_AKRJ_G0016285
 protein coding gene Chr1:94407611-94437808 (+)
BALB/cJ MGP_BALBcJ_G0016280
 protein coding gene Chr1:91881094-91912729 (+)
C3H/HeJ MGP_C3HHeJ_G0016109
 protein coding gene Chr1:94660835-94691528 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016739
 protein coding gene Chr1:98719909-98752103 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014457
 protein coding gene Chr1:85952381-85984167 (+)
CAST/EiJ MGP_CASTEiJ_G0015692
 protein coding gene Chr1:93991555-94023022 (+)
CBA/J MGP_CBAJ_G0016083
 protein coding gene Chr1:101912762-101947924 (+)
DBA/2J MGP_DBA2J_G0016188
 protein coding gene Chr1:90893416-90923632 (+)
FVB/NJ MGP_FVBNJ_G0016187
 protein coding gene Chr1:89969264-90000037 (+)
LP/J MGP_LPJ_G0016259
 protein coding gene Chr1:96284005-96315662 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016212
 protein coding gene Chr1:105019404-105053381 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016778
 protein coding gene Chr1:94421955-94454287 (+)
PWK/PhJ MGP_PWKPhJ_G0015477
 protein coding gene Chr1:90332924-90363409 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015261
 protein coding gene Chr1:93370345-93406366 (+)
WSB/EiJ MGP_WSBEiJ_G0015752
 protein coding gene Chr1:94240983-94274194 (+)



Homology
more
  • Human Ortholog
    SEPTIN2, septin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEPTIN2, septin 2
  • Synonyms
    DIFF6, hNedd5, NEDD5, NEDD-5, Pnutl3, SEPT2, Septin-2
  • Links
    NCBI Gene ID: 4735
    neXtProt AC: NX_Q15019
    UniProt: Q15019

  • Chr Location
    2q37.3; chr2:241315100-241354027 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    54
  • Tissues
    18
  • cDNA Data
    248
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18000 NCBI Gene Model | MGI Sequence Detail 30785 C57BL/6J ±  kb
    transcript NM_001421499 RefSeq | MGI Sequence Detail 3385 C57BL/6  
    polypeptide P42208 UniProt | EBI | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 251
      cDNA 248
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12811, MGI:2138573
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 11
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:339068 Martens AK, et al., Targeted inactivation of the Septin2 and Septin9 genes in myelinating Schwann cells of mice. Cytoskeleton (Hoboken). 2022 Nov 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory