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Hoxc12 Gene Detail
Summary
  • Symbol
    Hoxc12
  • Name
    homeobox C12
  • Synonyms
    Hox-3.8
  • Feature Type
    protein coding gene
  • IDs
    MGI:96194
    NCBI Gene: 15421
  • Member of
    Hoxc cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102845261-102847044 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96194
 protein coding gene Chr15:102845192-102847044 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022425
 protein coding gene Chr15:105171008-105172869 (+)
A/J MGP_AJ_G0022387
 protein coding gene Chr15:101015534-101017395 (+)
AKR/J MGP_AKRJ_G0022362
 protein coding gene Chr15:104084755-104086600 (+)
BALB/cJ MGP_BALBcJ_G0022391
 protein coding gene Chr15:101063149-101065010 (+)
C3H/HeJ MGP_C3HHeJ_G0022158
 protein coding gene Chr15:104160867-104162728 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022840
 protein coding gene Chr15:109067042-109068894 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020363
 protein coding gene Chr15:96785073-96786926 (+)
CAST/EiJ MGP_CASTEiJ_G0021684
 protein coding gene Chr15:105033087-105034937 (+)
CBA/J MGP_CBAJ_G0022127
 protein coding gene Chr15:112898305-112900166 (+)
DBA/2J MGP_DBA2J_G0022258
 protein coding gene Chr15:100285654-100287502 (+)
FVB/NJ MGP_FVBNJ_G0022234
 protein coding gene Chr15:99355129-99356977 (+)
LP/J MGP_LPJ_G0022327
 protein coding gene Chr15:105306636-105308497 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022256
 protein coding gene Chr15:116414933-116416781 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022852
 protein coding gene Chr15:104123495-104125347 (+)
PWK/PhJ MGP_PWKPhJ_G0021424
 protein coding gene Chr15:100464568-100466369 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021256
 protein coding gene Chr15:103953441-103955300 (+)
WSB/EiJ MGP_WSBEiJ_G0021734
 protein coding gene Chr15:104737855-104739709 (+)



Homology
more
  • Human Ortholog
    HOXC12, homeobox C12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXC12, homeobox C12
  • Synonyms
    HOC3F, HOX3, HOX3F
  • Links
    NCBI Gene ID: 3228
    neXtProt AC: NX_P31275
    UniProt: P31275

  • Chr Location
    12q13.13; chr12:53954903-53958956 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    65
  • cDNA Data
    7
  • Literature Summary
    19
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15421 NCBI Gene Model | MGI Sequence Detail 1784 C57BL/6J ±  kb
transcript NM_010463 RefSeq | MGI Sequence Detail 962 Not Specified  
polypeptide Q8K5B8 UniProt | EBI | MGI Sequence Detail 280 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 6
    cDNA 8
    Primer pair 4
    Other 3

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-10846, MGD-MRK-10895
References
more
  • Summaries
    All 69
    Developmental Gene Expression 19
    Diseases 1
    Gene Ontology 5
    Phenotypes 31
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:317804 Hauswirth GM, et al., Breaking constraint of mammalian axial formulae. Nat Commun. 2022 Jan 11;13(1):243
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory