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Grid1 Gene Detail
Summary
  • Symbol
    Grid1
  • Name
    glutamate receptor, ionotropic, delta 1
  • Synonyms
    GluRdelta1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95812
    NCBI Gene: 14803
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:34542065-35305336 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19444 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95812
 protein coding gene Chr14:34541751-35305344 (+)
129S1/SvImJ ENSMUSG00200037231
 protein coding gene Chr14:26372765-27129531 (+)
A/J ENSMUSG00195012187
 protein coding gene Chr14:27443373-28206723 (+)
AKR/J ENSMUSG00220033301
 protein coding gene Chr14:26563258-27330656 (+)
BALB/cJ ENSMUSG00180024541
 protein coding gene Chr14:26531852-27295185 (+)
C3H/HeJ ENSMUSG00175031990
 protein coding gene Chr14:26598834-27367176 (+)
C57BL/6NJ ENSMUSG00215022277
 protein coding gene Chr14:26842675-27606317 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019126
 protein coding gene Chr14:27101351-27837195 (+)
CAST/EiJ ENSTCUG00005021168
 protein coding gene Chr14:26651635-27401642 (+)
CBA/J ENSMUSG00210041930
 protein coding gene Chr14:26849785-27613077 (+)
DBA/2J ENSMUSG00185014384
 protein coding gene Chr14:31097883-31853811 (+)
FVB/NJ ENSMUSG00205017023
 protein coding gene Chr14:26699261-27468742 (+)
JF1/MsJ ENSUMUG00000034836
 protein coding gene Chr14:38363155-39120185 (+)
LP/J ENSMUSG00230037373
 protein coding gene Chr14:38399965-39157471 (+)
NOD/ShiLtJ ENSMUSG00190017593
 protein coding gene Chr14:26850838-27614129 (+)
NZO/HlLtJ ENSMUSG00225041636
 protein coding gene Chr14:32730392-33493670 (+)
PWK/PhJ ENSLUMG00010022076
 protein coding gene Chr14:14947620-15688461 (+)
SPRET/EiJ ENSMSPG00010040384
 protein coding gene Chr14:28527740-29292426 (+)
WSB/EiJ ENSIUOG00005011678
 protein coding gene Chr14:26667238-27419418 (+)



Homology
more
  • Human Ortholog
    GRID1, glutamate ionotropic receptor delta type subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRID1, glutamate ionotropic receptor delta type subunit 1
  • Synonyms
    GluD1, GluD1-b
  • Links
    NCBI Gene ID: 2894
    UniProt: Q9ULK0

  • Chr Location
    10q23.1-q23.2; chr10:85599552-86366795 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation display a significant high-frequency hearing loss, associated with reductions of both cochlear outer hair cell function and endolymphatic potential, as well as increased vulnerability to acoustic injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    84
  • cDNA Data
    9
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041078 Ensembl Gene Model | MGI Sequence Detail 763272 C57BL/6J ±  kb
    transcript ENSMUST00000043349 Ensembl | MGI Sequence Detail 5720 Not Applicable  
    polypeptide ENSMUSP00000044009 Ensembl | MGI Sequence Detail 1009 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 9
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10250
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 7
      Gene Ontology 15
      Phenotypes 17
    • Earliest
      J:320 Yamazaki M, et al., Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family. Biochem Biophys Res Commun. 1992 Mar 16;183(2):886-92
    • Latest
      J:389714 S Narasimhan KK, et al., Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain. Autophagy. 2025 Dec;21(12):3216-3239
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory