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Gnat2 Gene Detail
Summary
  • Symbol
    Gnat2
  • Name
    G protein subunit alpha transducin 2
  • Synonyms
    Gnat-2, Gt-2, Tcalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95779
    NCBI Gene: 14686
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108000105-108008748 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.83 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95779
 protein coding gene Chr3:107994120-108008748 (+)
129S1/SvImJ ENSMUSG00200034786
 protein coding gene Chr3:104616083-104624727 (+)
A/J ENSMUSG00195024430
 protein coding gene Chr3:105042519-105051165 (+)
AKR/J ENSMUSG00220030716
 protein coding gene Chr3:103406146-103414795 (+)
BALB/cJ ENSMUSG00180018162
 protein coding gene Chr3:104987862-104996498 (+)
C3H/HeJ ENSMUSG00175028429
 protein coding gene Chr3:104522640-104531283 (+)
C57BL/6NJ ENSMUSG00215026133
 protein coding gene Chr3:105250503-105259146 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025519
 protein coding gene Chr3:102297524-102312289 (+)
CAST/EiJ ENSTCUG00005025335
 protein coding gene Chr3:105521572-105530221 (+)
CBA/J ENSMUSG00210008078
 protein coding gene Chr3:105144495-105153137 (+)
DBA/2J ENSMUSG00185020899
 protein coding gene Chr3:105613832-105622476 (+)
FVB/NJ ENSMUSG00205022285
 protein coding gene Chr3:104180499-104189145 (+)
JF1/MsJ ENSUMUG00000003834
 protein coding gene Chr3:104589539-104597865 (+)
LP/J ENSMUSG00230019348
 protein coding gene Chr3:107529084-107537728 (+)
NOD/ShiLtJ ENSMUSG00190025963
 protein coding gene Chr3:105851922-105860565 (+)
NZO/HlLtJ ENSMUSG00225015981
 protein coding gene Chr3:110028913-110043440 (+)
PWK/PhJ ENSLUMG00010022866
 protein coding gene Chr3:104452800-104461129 (+)
SPRET/EiJ ENSMSPG00010029598
 protein coding gene Chr3:104954171-104962519 (+)
WSB/EiJ ENSIUOG00005004028
 protein coding gene Chr3:105166412-105175055 (+)



Homology
more
  • Human Ortholog
    GNAT2, G protein subunit alpha transducin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNAT2, G protein subunit alpha transducin 2
  • Synonyms
    ACHM4, GNATC, HG1D
  • Links
    NCBI Gene ID: 2780
    UniProt: P19087

  • Chr Location
    1p13.3; chr1:109601407-109619929 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Gnat2 mouse models; 2 with human GNAT2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    125 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in progressive degeneration of photoreceptors and normal ERG responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    102
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    657
  • Tissues
    25
  • cDNA Data
    27
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009108 Ensembl Gene Model | MGI Sequence Detail 8644 C57BL/6J ±  kb
    transcript ENSMUST00000058669 Ensembl | MGI Sequence Detail 2054 Not Applicable  
    polypeptide ENSMUSP00000053818 Ensembl | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008092 guanine nucleotide-binding protein G(t) subunit alpha-2
      (term hierarchy)
    • EC
      3.6.5.-
    • InterPro Domains
      IPR001408 G-protein alpha subunit, group I
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein, alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 28
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10191, MGD-MRK-10193, MGI:2139985
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 15
      Diseases 4
      Gene Ontology 30
      Phenotypes 125
    • Earliest
      J:30928 Lochrie MA, et al., Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. Science. 1985 Apr 5;228(4695):96-9
    • Latest
      J:389709 Unger L, et al., Defective HNF1A hinders GLI3 processing favoring duodenal versus pancreatic fate, thus leading to intestinal elongation in vivo. Genes Dev. 2026 Jun 1;40(11-12):805-831
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory