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Gna12 Gene Detail
Summary
  • Symbol
    Gna12
  • Name
    guanine nucleotide binding protein, alpha 12
  • Synonyms
    Galpha12
  • Feature Type
    protein coding gene
  • IDs
    MGI:95767
    NCBI Gene: 14673
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140745699-140816186 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 79.30 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1588 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95767
 protein coding gene Chr5:140744163-140816186 (-)
129S1/SvImJ ENSMUSG00200040935
 protein coding gene Chr5:134611659-134683676 (-)
A/J ENSMUSG00195045080
 protein coding gene Chr5:134235963-134307996 (-)
AKR/J ENSMUSG00220022471
 protein coding gene Chr5:133492631-133564657 (-)
BALB/cJ ENSMUSG00180030920
 protein coding gene Chr5:134336486-134408510 (-)
C3H/HeJ ENSMUSG00175044176
 protein coding gene Chr5:136257356-136335852 (-)
C57BL/6NJ ENSMUSG00215036986
 protein coding gene Chr5:134190238-134262264 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027956
 protein coding gene Chr5:133477286-133551517 (-)
CAST/EiJ ENSTCUG00005029625
 protein coding gene Chr5:133646254-133718395 (-)
CBA/J ENSMUSG00210022697
 protein coding gene Chr5:135074274-135152774 (-)
DBA/2J ENSMUSG00185053424
 protein coding gene Chr5:138089425-138161451 (-)
FVB/NJ ENSMUSG00205022857
 protein coding gene Chr5:133894519-133966547 (-)
JF1/MsJ ENSUMUG00000043909
 protein coding gene Chr5:140970735-141042666 (-)
LP/J ENSMUSG00230027457
 protein coding gene Chr5:142205162-142277189 (-)
NOD/ShiLtJ ENSMUSG00190037289
 protein coding gene Chr5:134031758-134103784 (-)
NZO/HlLtJ ENSMUSG00225023372
 protein coding gene Chr5:149679959-149751981 (-)
PWK/PhJ ENSLUMG00010018414
 protein coding gene Chr5:132692709-132764557 (-)
SPRET/EiJ ENSMSPG00010035849
 protein coding gene Chr5:136294119-136366554 (-)
WSB/EiJ ENSIUOG00005036559
 protein coding gene Chr5:136565554-136637601 (-)



Homology
more
  • Human Ortholog
    GNA12, G protein subunit alpha 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNA12, G protein subunit alpha 12
  • Synonyms
    gep, HG1M1, NNX3, RMP
  • Links
    NCBI Gene ID: 2768
    UniProt: Q03113

  • Chr Location
    7p22.3-p22.2; chr7:2721822-2870786 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    28 phenotypes from multigenic genotypes
    49 phenotype references
Mice deficient for this gene do not exhibit any detectable abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    72
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    673
  • Tissues
    51
  • cDNA Data
    7
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14673 NCBI Gene Model | MGI Sequence Detail 70488 C57BL/6J ±  kb
transcript NM_010302 RefSeq | MGI Sequence Detail 1880 ZRU/MplStud  
polypeptide P27600 UniProt | EBI | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008081 guanine nucleotide-binding protein subunit alpha-12
    (term hierarchy)
  • PDB
    1ZCA
  • InterPro Domains
    IPR000469 G-protein alpha subunit, group 12/13
    IPR011025 G protein alpha subunit, helical insertion
    IPR001019 Guanine nucleotide binding protein, alpha subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
  • GlyGen
    P27600 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
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  • All nucleic 17
    Genomic 2
    cDNA 7
    Primer pair 6
    Other 2

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10176, MGI:2140857, MGI:2140922
References
more
  • Summaries
    All 101
    Developmental Gene Expression 10
    Gene Ontology 16
    Phenotypes 49
  • Earliest
    J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
  • Latest
    J:381085 Kabir M, et al., A machine learning classifier to identify and prioritise genes associated with murine cardiac development. PLoS Genet. 2026 Feb;22(2):e1011489
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory