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Glra4 Gene Detail
Summary
  • Symbol
    Glra4
  • Name
    glycine receptor, alpha 4 subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:95750
    NCBI Gene: 14657
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:135658423-135680890 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 59.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    121 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95750
 protein coding gene ChrX:135655264-135683836 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036104
 protein coding gene ChrX:134168670-134192135 (-)
A/J MGP_AJ_G0036085
 protein coding gene ChrX:133562784-133585475 (-)
AKR/J MGP_AKRJ_G0036009
 protein coding gene ChrX:137836180-137860564 (-)
BALB/cJ MGP_BALBcJ_G0036074
 protein coding gene ChrX:131965042-131987133 (-)
C3H/HeJ MGP_C3HHeJ_G0035783
 protein coding gene ChrX:134207173-134227678 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036598
 protein coding gene ChrX:138064151-138086551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033425
 protein coding gene ChrX:125518259-125537281 (-)
CAST/EiJ MGP_CASTEiJ_G0035071
 protein coding gene ChrX:115003773-115024366 (-)
CBA/J MGP_CBAJ_G0035759
 protein coding gene ChrX:142316919-142339784 (-)
DBA/2J MGP_DBA2J_G0035916
 protein coding gene ChrX:132866627-132893980 (-)
FVB/NJ MGP_FVBNJ_G0035850
 protein coding gene ChrX:132073590-132094118 (-)
LP/J MGP_LPJ_G0036010
 protein coding gene ChrX:135137626-135159721 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035886
 protein coding gene ChrX:149610309-149630911 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036635
 protein coding gene ChrX:133538569-133560374 (-)
PWK/PhJ MGP_PWKPhJ_G0034764
 protein coding gene ChrX:112029134-112050119 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034592
 protein coding gene ChrX:115627057-115647617 (-)
WSB/EiJ MGP_WSBEiJ_G0035206
 protein coding gene ChrX:131856854-131877870 (-)



Homology
more
  • Human Ortholog
    GLRA4, glycine receptor alpha 4 (pseudogene)
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLRA4, glycine receptor alpha 4 (pseudogene)
  • Links
    NCBI Gene ID: 441509

  • Chr Location
    Xq22.2; chrX:103705494-103728495 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018595 Ensembl Gene Model | MGI Sequence Detail 22468 C57BL/6J ±  kb
    transcript ENSMUST00000018739 Ensembl | MGI Sequence Detail 1831 Not Applicable  
    polypeptide ENSMUSP00000018739 Ensembl | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008045 glycine receptor subunit alpha-4
      (term hierarchy)
    • InterPro Domains
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR008127 Glycine receptor alpha
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 7
      Genomic 2
      cDNA 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10133
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:16637 Matzenbach B, et al., Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant. J Biol Chem. 1994 Jan 28;269(4):2607-12
    • Latest
      J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory