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Gli2 Gene Detail
Summary
  • Symbol
    Gli2
  • Name
    GLI-Kruppel family member GLI2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95728
    NCBI Gene: 14633
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
  • Regulated by
    Rr214 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr1:118761862-118981349 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.17 cM, cytoband E2-E4
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5685 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95728
 protein coding gene Chr1:118761791-118987578 (-)
129S1/SvImJ ENSMUSG00200001471
 protein coding gene Chr1:116235681-116455263 (-)
A/J ENSMUSG00195004529
 protein coding gene Chr1:115476372-115696066 (-)
AKR/J ENSMUSG00220024670
 protein coding gene Chr1:115293476-115512918 (-)
BALB/cJ ENSMUSG00180012212
 protein coding gene Chr1:115885346-116104928 (-)
C3H/HeJ ENSMUSG00175018883
 protein coding gene Chr1:115707355-115927033 (-)
C57BL/6NJ ENSMUSG00215008633
 protein coding gene Chr1:115668455-115888372 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014510
 protein coding gene Chr1:110877319-111100852 (-)
CAST/EiJ ENSTCUG00005006371
 protein coding gene Chr1:114616425-114837846 (-)
CBA/J ENSMUSG00210001261
 protein coding gene Chr1:115537017-115756690 (-)
DBA/2J ENSMUSG00185013583
 protein coding gene Chr1:119985182-120204873 (-)
FVB/NJ ENSMUSG00205011772
 protein coding gene Chr1:115038658-115258192 (-)
JF1/MsJ ENSUMUG00000022293
 protein coding gene Chr1:119084032-119305247 (-)
LP/J ENSMUSG00230008414
 protein coding gene Chr1:119413585-119633142 (-)
NOD/ShiLtJ ENSMUSG00190006411
 protein coding gene Chr1:115522204-115741869 (-)
NZO/HlLtJ ENSMUSG00225004166
 protein coding gene Chr1:123203922-123423593 (-)
PWK/PhJ ENSLUMG00010014496
 protein coding gene Chr1:114661710-114883501 (-)
SPRET/EiJ ENSMSPG00010016616
 protein coding gene Chr1:117296672-117518085 (-)
WSB/EiJ ENSIUOG00005002746
 protein coding gene Chr1:115390032-115609591 (-)



Homology
more
  • Human Ortholog
    GLI2, GLI family zinc finger 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLI2, GLI family zinc finger 2
  • Synonyms
    CJS, HPE9, PHS2, THP1, THP2
  • Links
    NCBI Gene ID: 2736
    UniProt: P10070

  • Chr Location
    2q14.2; chr2:120735623-120992653 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human GLI2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    93 phenotypes from 7 alleles in 16 genetic backgrounds
    117 phenotypes from multigenic genotypes
    1 images
    214 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit skeletal malformations, absence of floorplate and foregut, lung and anorectal defects, and altered commissural neuron guidance. Most mutants die before embryonic day 18.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    161
  • GO References
    72
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1327
  • Tissues
    381
  • cDNA Data
    56
  • Literature Summary
    290
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048402 Ensembl Gene Model | MGI Sequence Detail 219488 C57BL/6J ±  kb
    transcript ENSMUST00000062483 Ensembl | MGI Sequence Detail 6637 Not Applicable  
    polypeptide ENSMUSP00000054837 Ensembl | MGI Sequence Detail 1544 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      Genomic 3
      cDNA 57
      Primer pair 26
      Other 21
      Antibodies 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10106, MGI:2138602
    References
    more
    • Summaries
      All 569
      Developmental Gene Expression 290
      Diseases 1
      Gene Ontology 72
      Phenotypes 214
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:388049 Nicol B, et al., A New Constitutive Foxl2-Cre Mouse Model Reveals Foxl2-Derived Cell Fate in Reproductive and Non-Reproductive Tissues. Biol Reprod. 2026 Jun 3;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory