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Galnt1 Gene Detail
Summary
  • Symbol
    Galnt1
  • Name
    polypeptide N-acetylgalactosaminyltransferase 1
  • Synonyms
    ppGaNTase-T1
  • Feature Type
    protein coding gene
  • IDs
    MGI:894693
    NCBI Gene: 14423
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:24338401-24419873 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 12.90 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894693
 protein coding gene Chr18:24338401-24419875 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024199
 protein coding gene Chr18:21937195-22022743 (+)
A/J MGP_AJ_G0024164
 protein coding gene Chr18:21339411-21428068 (+)
AKR/J MGP_AKRJ_G0024133
 protein coding gene Chr18:21993507-22077147 (+)
BALB/cJ MGP_BALBcJ_G0024164
 protein coding gene Chr18:21388550-21470206 (+)
C3H/HeJ MGP_C3HHeJ_G0023932
 protein coding gene Chr18:21923486-22007308 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024606
 protein coding gene Chr18:22868220-22962572 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022048
 protein coding gene Chr18:21208646-21289771 (+)
CAST/EiJ MGP_CASTEiJ_G0023406
 protein coding gene Chr18:21706429-21799530 (+)
CBA/J MGP_CBAJ_G0023900
 protein coding gene Chr18:23491282-23596297 (+)
DBA/2J MGP_DBA2J_G0024032
 protein coding gene Chr18:21008240-21091614 (+)
FVB/NJ MGP_FVBNJ_G0023998
 protein coding gene Chr18:20766490-20849884 (+)
LP/J MGP_LPJ_G0024113
 protein coding gene Chr18:22097071-22186615 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024026
 protein coding gene Chr18:24494918-24585641 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024654
 protein coding gene Chr18:21744428-21837304 (+)
PWK/PhJ MGP_PWKPhJ_G0023150
 protein coding gene Chr18:21147560-21231576 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022959
 protein coding gene Chr18:21979256-22076917 (+)
WSB/EiJ MGP_WSBEiJ_G0023470
 protein coding gene Chr18:21638268-21726656 (+)



Homology
more
  • Human Ortholog
    GALNT1, polypeptide N-acetylgalactosaminyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALNT1, polypeptide N-acetylgalactosaminyltransferase 1
  • Synonyms
    GALNAC-T1
  • Links
    NCBI Gene ID: 2589
    neXtProt AC: NX_Q10472
    UniProt: Q10472

  • Chr Location
    18q12.2; chr18:35580922-35711834 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Galnt1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit some embryonic lethality, increased bleeding time, decreased T and B cells, impaired leukocyte rolling, decreased IgG levels, and hypoalbuminemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1084
  • Tissues
    180
  • cDNA Data
    185
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14423 NCBI Gene Model | MGI Sequence Detail 81473 C57BL/6J ±  kb
    transcript NM_001361200 RefSeq | MGI Sequence Detail 4193 C57BL/6  
    polypeptide O08912 UniProt | EBI | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 189
      cDNA 185
      Primer pair 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:40489 Hagen FK, et al., cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 1997 May 23;272(21):13843-8
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory