Cyp11b1 MGI Mouse Gene Detail - MGI:88583 - cytochrome P450, family 11, subfamily b, polypeptide 1

Symbol

Cyp11b1
Name

cytochrome P450, family 11, subfamily b, polypeptide 1
Synonyms

Cyp11b, Cyp11b-1

Feature Type

protein coding gene
IDs

MGI:88583
NCBI Gene: 110115
Alliance

genome feature page
Transcription Start Sites

11 TSS

Sequence Map

Chr15:74706741-74713492 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 34.29 cM
Mapping Data

4 experiments

SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

17
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88583	protein coding gene	Chr15:74705974-74713492 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021942	protein coding gene	Chr15:74623753-74634083 (-)
A/J	no annotation
AKR/J	MGP_AKRJ_G0021883	protein coding gene	Chr15:73818724-73826636 (-)
BALB/cJ	MGP_BALBcJ_G0021908	protein coding gene	Chr15:71973698-71995102 (-)
C3H/HeJ	MGP_C3HHeJ_G0021681	protein coding gene	Chr15:73967715-73977492 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022348	protein coding gene	Chr15:77445222-77454664 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019883	protein coding gene	Chr15:68361004-68368419 (-)
CAST/EiJ	MGP_CASTEiJ_G0021200	protein coding gene	Chr15:74789189-74801972 (-)
CBA/J	MGP_CBAJ_G0021647	protein coding gene	Chr15:79984832-79995333 (-)
DBA/2J	MGP_DBA2J_G0021772	protein coding gene	Chr15:71558570-71566456 (-)
FVB/NJ	MGP_FVBNJ_G0021754	protein coding gene	Chr15:70599906-70607190 (-)
LP/J	MGP_LPJ_G0021844	protein coding gene	Chr15:74699819-74708587 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021777	protein coding gene	Chr15:85282165-85290995 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022369	protein coding gene	Chr15:74200595-74213220 (-)
PWK/PhJ	MGP_PWKPhJ_G0020939	protein coding gene	Chr15:71664238-71690587 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020780	protein coding gene	Chr15:74051476-74058209 (+)
WSB/EiJ	MGP_WSBEiJ_G0021252	protein coding gene	Chr15:74216002-74231371 (-)

Human Ortholog

CYP11B1, cytochrome P450 family 11 subfamily B member 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP11B1, cytochrome P450 family 11 subfamily B member 1
Synonyms

CPN1, CYP11B, FHI, P450C11
Links

HGNC:2591

NCBI Gene ID: 1584

UniProt: P15538
Chr Location

8q24.3; chr8:142871528-142880000 (-) GRCh38

Human Ortholog

CYP11B2, cytochrome P450 family 11 subfamily B member 2
Synonyms

ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P450aldo, P-450C18, P450C18
Links

HGNC:2592

NCBI Gene ID: 1585

UniProt: P19099
Chr Location

8q24.3; chr8:142910559-142917850 (-) GRCh38

MGI Vertebrate Homology

Cyp11b1 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYP11B1, CYP11B2
Gene Tree

Cyp11b1

Diseases

1 with Cyp11b1 mouse models; 10 with human CYP11B1,CYP11B2 associations

Human Disease

Mouse Models

congenital adrenal hyperplasia

IDs

View 1 model

corticosterone methyloxidase deficiency 1

IDs

diabetes mellitus

IDs

dilated cardiomyopathy 1H

IDs

glucocorticoid-remediable aldosteronism

IDs

hypertension

IDs

pre-eclampsia

IDs

primary hyperaldosteronism

IDs

stroke

IDs

type 2 diabetes mellitus

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

27 phenotypes from 1 allele in 1 genetic background
2 images
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

3
Endonuclease-mediated

2
Radiation induced

2
Targeted

5
Genomic Mutations

5 involving Cyp11b1
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit adrenal hypertrophy, abnormal organ weights, abnormal hormone levels, abnormal urine chemistry, hypokalemia, increased blood pressure, and female infertility.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

832
Tissues

108
cDNA Data

11
Literature Summary

32

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

35
RefSeq

3
UniProt

4
CCDS

CCDS27535.1

Ensembl

ENSMUSG00000075604 (Evidence)
NCBI Gene

110115

			Length	Strain/Species	Flank
genomic	110115	NCBI Gene Model \| MGI Sequence Detail	6752	C57BL/6J	± kb
transcript	NM_001033229	RefSeq \| MGI Sequence Detail	2373	C57BL/6
polypeptide	NP_001028401	RefSeq \| MGI Sequence Detail	499	C57BL/6

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UniProt

4 Sequences
EC

1.14.15.4
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR050479 Cytochrome P450, families 11 and 27

IPR002399 Cytochrome P450, mitochondrial

IPR036396 Cytochrome P450 superfamily

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All nucleic 22

Genomic 1

cDNA 12

Primer pair 8

Other 1

Antibodies 1

Microarray probesets 2

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MGD-MRK-2292, MGD-MRK-2293, MGD-MRK-2295, MGI:3035249

Summaries

All 92

Developmental Gene Expression 32

Diseases 2

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Cyp11b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134795	Chr15:74714467-74714477 (-)	-980 bp
Tssr134794	Chr15:74714445-74714458 (-)	-960 bp
Tssr134793	Chr15:74714431-74714439 (-)	-943 bp
Tssr134792	Chr15:74713650-74713665 (-)	-166 bp
Tssr134791	Chr15:74713604-74713613 (-)	-117 bp
Tssr134790	Chr15:74713459-74713482 (-)	21 bp
Tssr134789	Chr15:74710923-74710933 (-)	2,564 bp
Tssr134788	Chr15:74710885-74710894 (-)	2,602 bp
Tssr134787	Chr15:74710443-74710468 (-)	3,036 bp
Tssr134786	Chr15:74708813-74708859 (-)	4,656 bp
Tssr134785	Chr15:74708117-74708138 (-)	5,364 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 06/09/2026 MGI 6.24