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Ckm Gene Detail
Summary
  • Symbol
    Ckm
  • Name
    creatine kinase, muscle
  • Synonyms
    Ckmm, MCK, M-CK
  • Feature Type
    protein coding gene
  • IDs
    MGI:88413
    NCBI Gene: 12715
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19145019-19155508 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.67 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88413
 protein coding gene Chr7:19138701-19156766 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031776
 protein coding gene Chr7:17410449-17420972 (+)
A/J MGP_AJ_G0031752
 protein coding gene Chr7:17057072-17067376 (+)
AKR/J MGP_AKRJ_G0031678
 protein coding gene Chr7:17529530-17539694 (+)
BALB/cJ MGP_BALBcJ_G0031757
 protein coding gene Chr7:17258140-17268543 (+)
C3H/HeJ MGP_C3HHeJ_G0031479
 protein coding gene Chr7:17788855-17800299 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032223
 protein coding gene Chr7:18285978-18296290 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029289
 protein coding gene Chr7:18702580-18713159 (+)
CAST/EiJ MGP_CASTEiJ_G0030822
 protein coding gene Chr7:14200364-14221287 (+)
CBA/J MGP_CBAJ_G0031441
 protein coding gene Chr7:18944105-18954627 (+)
DBA/2J MGP_DBA2J_G0031596
 protein coding gene Chr7:16998927-17009691 (+)
FVB/NJ MGP_FVBNJ_G0031548
 protein coding gene Chr7:16860962-16871264 (+)
LP/J MGP_LPJ_G0031679
 protein coding gene Chr7:17733722-17744249 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031584
 protein coding gene Chr7:18802025-18812535 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032251
 protein coding gene Chr7:17127153-17137308 (+)
PWK/PhJ MGP_PWKPhJ_G0030546
 protein coding gene Chr7:14092591-14103469 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030373
 protein coding gene Chr7:11837761-11850306 (+)
WSB/EiJ MGP_WSBEiJ_G0030922
 protein coding gene Chr7:17351608-17363401 (+)



Homology
more
  • Human Ortholog
    CKM, creatine kinase, M-type
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CKM, creatine kinase, M-type
  • Synonyms
    CKMM, CPK-M, M-CK
  • Links
    NCBI Gene ID: 1158
    neXtProt AC: NX_P06732
    UniProt: P06732

  • Chr Location
    19q13.32; chr19:45306413-45322875 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 1 genetic background
    10 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in function and energy utilization of both skeletal and cardiac muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1086
  • Tissues
    172
  • cDNA Data
    165
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12715 NCBI Gene Model | MGI Sequence Detail 10490 C57BL/6J ±  kb
    transcript NM_007710 RefSeq | MGI Sequence Detail 1415 ZRU/MplStud  
    polypeptide P07310 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000005515 creatine kinase M-type
      (term hierarchy)
    • EC
      2.7.3.2
    • InterPro Domains
      IPR000749 ATP:guanido phosphotransferase
      IPR022415 ATP:guanido phosphotransferase active site
      IPR022414 ATP:guanido phosphotransferase, catalytic domain
      IPR022413 ATP:guanido phosphotransferase, N-terminal
      IPR036802 ATP:guanido phosphotransferase, N-terminal domain superfamily
      IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 185
      Genomic 3
      cDNA 169
      Primer pair 9
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2003
    References
    more
    • Summaries
      All 139
      Developmental Gene Expression 41
      Gene Ontology 10
      Phenotypes 37
    • Earliest
      J:7361 Bulfield G, et al., X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A. 1984 Feb;81(4):1189-92
    • Latest
      J:340833 Cai S, et al., KLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer. Cell Death Dis. 2023 Sep 18;14(9):612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory