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Cbln2 Gene Detail
Summary
  • Symbol
    Cbln2
  • Name
    cerebellin 2 precursor protein
  • Synonyms
    6330593N19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:88282
    NCBI Gene: 12405
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:86729235-86736408 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 58.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88282
 protein coding gene Chr18:86727226-86736410 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024614
 protein coding gene Chr18:87934369-87941540 (+)
A/J MGP_AJ_G0024581
 protein coding gene Chr18:84083230-84090403 (+)
AKR/J MGP_AKRJ_G0024552
 protein coding gene Chr18:86576770-86583943 (+)
BALB/cJ MGP_BALBcJ_G0024579
 protein coding gene Chr18:84294774-84301947 (+)
C3H/HeJ MGP_C3HHeJ_G0024348
 protein coding gene Chr18:86682963-86690136 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025026
 protein coding gene Chr18:90160488-90167661 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022457
 protein coding gene Chr18:82600040-82607191 (+)
CAST/EiJ MGP_CASTEiJ_G0023821
 protein coding gene Chr18:87079088-87086251 (+)
CBA/J MGP_CBAJ_G0024318
 protein coding gene Chr18:93383367-93390540 (+)
DBA/2J MGP_DBA2J_G0024447
 protein coding gene Chr18:83606966-83614139 (+)
FVB/NJ MGP_FVBNJ_G0024414
 protein coding gene Chr18:82964519-82971692 (+)
LP/J MGP_LPJ_G0024532
 protein coding gene Chr18:87763695-87770866 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024444
 protein coding gene Chr18:94777123-94784296 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025075
 protein coding gene Chr18:86820117-86827288 (+)
PWK/PhJ MGP_PWKPhJ_G0023566
 protein coding gene Chr18:83983999-83991165 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023372
 protein coding gene Chr18:86823161-86830343 (+)
WSB/EiJ MGP_WSBEiJ_G0023883
 protein coding gene Chr18:86727802-86734972 (+)



Homology
more
  • Human Ortholog
    CBLN2, cerebellin 2 precursor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBLN2, cerebellin 2 precursor
  • Links
    NCBI Gene ID: 147381
    neXtProt AC: NX_Q8IUK8
    UniProt: Q8IUK8

  • Chr Location
    18q22.3; chr18:72536680-72638521 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    187 phenotype references
No overt anatomical or neuroanatomical defects are observed in mice homozygous for deletion of this gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    966
  • Tissues
    61
  • cDNA Data
    23
  • Literature Summary
    20
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024647 Ensembl Gene Model | MGI Sequence Detail 7174 C57BL/6J ±  kb
transcript ENSMUST00000068423 Ensembl | MGI Sequence Detail 2475 Not Applicable  
polypeptide ENSMUSP00000068863 Ensembl | MGI Sequence Detail 224 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 23
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1785, MGI:2443422
References
more
  • Summaries
    All 230
    Developmental Gene Expression 20
    Diseases 2
    Gene Ontology 8
    Phenotypes 187
  • Earliest
    J:21224 Kavety B, et al., Genomic structure and mapping of precerebellin and a precerebellin-related gene. Brain Res Mol Brain Res. 1994 Nov;27(1):152-6
  • Latest
    J:344238 Zheng Y, et al., Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities. Cell Rep. 2023 Dec 26;42(12):113496
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory