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Blk Gene Detail
Summary
  • Symbol
    Blk
  • Name
    Blk proto-oncogene, Src family tyrosine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88169
    NCBI Gene: 12143
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63610285-63654486 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.25 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1402 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88169
 protein coding gene Chr14:63610285-63654636 (-)
129S1/SvImJ ENSMUSG00200029592
 protein coding gene Chr14:52218422-52262721 (-)
A/J ENSMUSG00195014105
 protein coding gene Chr14:52409984-52454253 (-)
AKR/J ENSMUSG00220029046
 protein coding gene Chr14:51750494-51794759 (-)
BALB/cJ ENSMUSG00180032744
 protein coding gene Chr14:52026092-52070355 (-)
C3H/HeJ ENSMUSG00175031661
 protein coding gene Chr14:53754755-53799054 (-)
C57BL/6NJ ENSMUSG00215024764
 protein coding gene Chr14:51942806-51987038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019404
 protein coding gene Chr14:54525996-54568835 (-)
CAST/EiJ ENSTCUG00005038196
 protein coding gene Chr14:53677545-53721976 (-)
CBA/J ENSMUSG00210034819
 protein coding gene Chr14:52397477-52441740 (-)
DBA/2J ENSMUSG00185029019
 protein coding gene Chr14:57552557-57596856 (-)
FVB/NJ ENSMUSG00205028237
 protein coding gene Chr14:51912867-51957140 (-)
JF1/MsJ ENSUMUG00000034619
 protein coding gene Chr14:68740904-68785313 (-)
LP/J ENSMUSG00230033539
 protein coding gene Chr14:69582102-69626394 (-)
NOD/ShiLtJ ENSMUSG00190028295
 protein coding gene Chr14:52192262-52236521 (-)
NZO/HlLtJ ENSMUSG00225046430
 protein coding gene Chr14:59925268-59969534 (-)
PWK/PhJ ENSLUMG00010030853
 protein coding gene Chr14:51624782-51669128 (-)
SPRET/EiJ ENSMSPG00010032612
 protein coding gene Chr14:55110077-55150977 (-)
WSB/EiJ ENSIUOG00005039335
 protein coding gene Chr14:51628502-51672951 (-)



Homology
more
  • Human Ortholog
    BLK, BLK proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BLK, BLK proto-oncogene, Src family tyrosine kinase
  • Synonyms
    MODY11
  • Links
    NCBI Gene ID: 640
    UniProt: P51451

  • Chr Location
    8p23.1; chr8:11486894-11564599 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human BLK associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show attenuated TRL/IL-1R-mediated inflammatory responses. Another allele shows no phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    670
  • Tissues
    50
  • cDNA Data
    29
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014453 Ensembl Gene Model | MGI Sequence Detail 44202 C57BL/6J ±  kb
    transcript ENSMUST00000014597 Ensembl | MGI Sequence Detail 2326 Not Applicable  
    polypeptide ENSMUSP00000014597 Ensembl | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 5
      cDNA 29
      Primer pair 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1577
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 22
    • Earliest
      J:10210 Dymecki SM, et al., Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6
    • Latest
      J:375901 Li WW, et al., BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation. J Cell Biol. 2024 Feb 5;223(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory