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Pdzrn4 Gene Detail
Summary
  • Symbol
    Pdzrn4
  • Name
    PDZ domain containing RING finger 4
  • Synonyms
    1110017D07Rik, LNX4, mKIAA3027, SAMCAP3L
  • Feature Type
    protein coding gene
  • IDs
    MGI:3056996
    NCBI Gene: 239618
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:92294762-92669700 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 46.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    10633 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3056996
 protein coding gene Chr15:92294691-92669700 (+)
129S1/SvImJ ENSMUSG00200034726
 protein coding gene Chr15:89443806-89819370 (+)
A/J ENSMUSG00195019438
 protein coding gene Chr15:89351175-89716530 (+)
AKR/J ENSMUSG00220030202
 protein coding gene Chr15:89379842-89754825 (+)
BALB/cJ ENSMUSG00180014896
 protein coding gene Chr15:89222158-89597148 (+)
C3H/HeJ ENSMUSG00175024472
 protein coding gene Chr15:89537660-89902975 (+)
C57BL/6NJ ENSMUSG00215013298
 protein coding gene Chr15:89330276-89705262 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020188
 protein coding gene Chr15:86246719-86603011 (+)
CAST/EiJ ENSTCUG00005028817
 protein coding gene Chr15:88856489-89222088 (+)
CBA/J ENSMUSG00210013081
 protein coding gene Chr15:89319065-89684378 (+)
DBA/2J ENSMUSG00185021572
 protein coding gene Chr15:89367194-89732526 (+)
FVB/NJ ENSMUSG00205021623
 protein coding gene Chr15:89073270-89438603 (+)
JF1/MsJ ENSUMUG00000025490
 protein coding gene Chr15:88875675-89234923 (+)
LP/J ENSMUSG00230035810
 protein coding gene Chr15:92681783-93057339 (+)
NOD/ShiLtJ ENSMUSG00190022166
 protein coding gene Chr15:89361165-89726483 (+)
NZO/HlLtJ ENSMUSG00225041321
 protein coding gene Chr15:92988774-93354520 (+)
PWK/PhJ ENSLUMG00010028849
 protein coding gene Chr15:89019148-89384462 (+)
SPRET/EiJ ENSMSPG00010013095
 protein coding gene Chr15:90825497-91194561 (+)
WSB/EiJ ENSIUOG00005010172
 protein coding gene Chr15:89423034-89799759 (+)



Homology
more
  • Human Ortholog
    PDZRN4, PDZ domain containing ring finger 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDZRN4, PDZ domain containing ring finger 4
  • Synonyms
    LNX4, SAMCAP3L
  • Links
    NCBI Gene ID: 29951
    UniProt: Q6ZMN7

  • Chr Location
    12q12; chr12:41188320-41574745 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Pdzrn4
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    40 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    686
  • Tissues
    20
  • cDNA Data
    8
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036218 Ensembl Gene Model | MGI Sequence Detail 374939 C57BL/6J ±  kb
transcript ENSMUST00000169942 Ensembl | MGI Sequence Detail 3102 Not Applicable  
polypeptide ENSMUSP00000133159 Ensembl | MGI Sequence Detail 1014 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920967
References
more
  • Summaries
    All 49
    Developmental Gene Expression 3
    Diseases 1
    Phenotypes 27
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:391648 Li H, et al., PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation. Oncogene. 2026 Feb;45(4):577-590
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory