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Adamts3 Gene Detail
Summary
  • Symbol
    Adamts3
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 3
  • Synonyms
    1100001H14Rik, 6330442E02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045353
    NCBI Gene: 330119
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:89824946-90031193 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 44.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5922 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045353
 protein coding gene Chr5:89821700-90031521 (-)
129S1/SvImJ ENSMUSG00200008195
 protein coding gene Chr5:85537281-85748741 (-)
A/J ENSMUSG00195024810
 protein coding gene Chr5:84727253-84933626 (-)
AKR/J ENSMUSG00220010952
 protein coding gene Chr5:84870490-85076862 (-)
BALB/cJ ENSMUSG00180024743
 protein coding gene Chr5:84569619-84779530 (-)
C3H/HeJ ENSMUSG00175036852
 protein coding gene Chr5:86664924-86874739 (-)
C57BL/6NJ ENSMUSG00215026142
 protein coding gene Chr5:85420182-85626547 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027383
 protein coding gene Chr5:82882625-83090097 (-)
CAST/EiJ ENSTCUG00005036488
 protein coding gene Chr5:84340393-84548263 (-)
CBA/J ENSMUSG00210005954
 protein coding gene Chr5:85464814-85674636 (-)
DBA/2J ENSMUSG00185036410
 protein coding gene Chr5:87378865-87588761 (-)
FVB/NJ ENSMUSG00205020963
 protein coding gene Chr5:84268193-84478133 (-)
JF1/MsJ ENSUMUG00000032338
 protein coding gene Chr5:91680867-91891134 (-)
LP/J ENSMUSG00230024702
 protein coding gene Chr5:92063702-92275153 (-)
NOD/ShiLtJ ENSMUSG00190030382
 protein coding gene Chr5:84333079-84557069 (-)
NZO/HlLtJ ENSMUSG00225008798
 protein coding gene Chr5:97211239-97422701 (-)
PWK/PhJ ENSLUMG00010027605
 protein coding gene Chr5:84343981-84560560 (-)
SPRET/EiJ ENSMSPG00010030004
 protein coding gene Chr5:86749773-86959495 (-)
WSB/EiJ ENSIUOG00005025850
 protein coding gene Chr5:87365613-87569929 (-)



Homology
more
  • Human Ortholog
    ADAMTS3, ADAM metallopeptidase with thrombospondin type 1 motif 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS3, ADAM metallopeptidase with thrombospondin type 1 motif 3
  • Synonyms
    ADAMTS-4, HKLLS3
  • Links
    NCBI Gene ID: 9508
    UniProt: O15072

  • Chr Location
    4q13.3; chr4:72280969-72569221 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADAMTS3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit lethality after E15, edema, absent lymphatic vessels, liver degeneration, and abnormal placenta labyrinth morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    4
  • cDNA Data
    28
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043635 Ensembl Gene Model | MGI Sequence Detail 206248 C57BL/6J ±  kb
    transcript ENSMUST00000163159 Ensembl | MGI Sequence Detail 3937 Not Applicable  
    polypeptide ENSMUSP00000132219 Ensembl | MGI Sequence Detail 1204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR013273 ADAMTS/ADAMTS-like
      IPR045371 ADAMTS/ADAMTS-like, cysteine-rich domain 3
      IPR010294 ADAMTS/ADAMTS-like, Spacer 1
      IPR050439 ADAMTS and ADAMTS-like
      IPR041645 ADAMTS, cysteine-rich domain 2
      IPR024079 Metallopeptidase, catalytic domain superfamily
      IPR001590 Peptidase M12B, ADAM/reprolysin
      IPR002870 Peptidase M12B, propeptide
      IPR010909 PLAC
      IPR036383 Thrombospondin type-1 repeat superfamily
      IPR000884 Thrombospondin type-1 (TSP1) repeat
    • GlyGen
      E9Q287 4 sites, 3 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 28
      Primer pair 1
      Other 2

      Microarray probesets 16
    Other
    Accession IDs
    less
    MGI:1915676
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 15
      Gene Ontology 5
      Phenotypes 24
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:379177 Gaudi AU, et al., Convergent evolution of scavenger cell development at brain borders. Nature. 2026 Jan 21;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory