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Trim67 Gene Detail
Summary
  • Symbol
    Trim67
  • Name
    tripartite motif-containing 67
  • Synonyms
    D130049O21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045323
    NCBI Gene: 330863
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:125519831-125561452 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    420 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045323
 protein coding gene Chr8:125518056-125561452 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034278
 protein coding gene Chr8:128501543-128546969 (+)
A/J MGP_AJ_G0034258
 protein coding gene Chr8:123177431-123214935 (+)
AKR/J MGP_AKRJ_G0034185
 protein coding gene Chr8:126730346-126776498 (+)
BALB/cJ MGP_BALBcJ_G0034251
 protein coding gene Chr8:123358851-123400662 (+)
C3H/HeJ MGP_C3HHeJ_G0033962
 protein coding gene Chr8:127376665-127423928 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034771
 protein coding gene Chr8:132790364-132833797 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031712
 protein coding gene Chr8:115936482-115977072 (+)
CAST/EiJ MGP_CASTEiJ_G0033289
 protein coding gene Chr8:127499493-127546851 (+)
CBA/J MGP_CBAJ_G0033935
 protein coding gene Chr8:137665819-137711882 (+)
DBA/2J MGP_DBA2J_G0034091
 protein coding gene Chr8:122333526-122375875 (+)
FVB/NJ MGP_FVBNJ_G0034035
 protein coding gene Chr8:121511984-121557129 (+)
LP/J MGP_LPJ_G0034180
 protein coding gene Chr8:128663013-128706237 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034082
 protein coding gene Chr8:139749928-139795110 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034790
 protein coding gene Chr8:126969959-127014349 (+)
PWK/PhJ MGP_PWKPhJ_G0032991
 protein coding gene Chr8:122093946-122137285 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032830
 protein coding gene Chr8:125590795-125641844 (+)
WSB/EiJ MGP_WSBEiJ_G0033406
 protein coding gene Chr8:127687221-127732142 (+)



Homology
more
  • Human Ortholog
    TRIM67, tripartite motif containing 67
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM67, tripartite motif containing 67
  • Synonyms
    TNL
  • Links
    NCBI Gene ID: 440730
    neXtProt AC: NX_Q6ZTA4
    UniProt: Q6ZTA4

  • Chr Location
    1q42.2; chr1:231162058-231221565 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display decreased brain size with forebrain abnormalities, impaired spatial learning, decreased response to social novelty, impaired coordiation and reduced grip strength.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    33
  • cDNA Data
    67
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036913 Ensembl Gene Model | MGI Sequence Detail 41622 C57BL/6J ±  kb
    transcript ENSMUST00000167588 Ensembl | MGI Sequence Detail 8735 Not Applicable  
    polypeptide ENSMUSP00000130343 Ensembl | MGI Sequence Detail 768 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 67

      Microarray probesets 3
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:185071 Yaguchi H, et al., TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis. J Biol Chem. 2012 Apr 6;287(15):12050-9
    • Latest
      J:340527 Cai C, et al., TRIM67 Implicates in Regulating the Homeostasis and Synaptic Development of Mitral Cells in the Olfactory Bulb. Int J Mol Sci. 2023 Aug 30;24(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory