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Neil2 Gene Detail
Summary
  • Symbol
    Neil2
  • Name
    nei like 2 (E. coli)
  • Synonyms
    LOC382913, NEH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2686058
    NCBI Gene: 382913
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63419892-63431305 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    394 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2686058
 protein coding gene Chr14:63419888-63431604 (-)
129S1/SvImJ ENSMUSG00200028842
 protein coding gene Chr14:52021381-52032476 (-)
A/J ENSMUSG00195029861
 protein coding gene Chr14:52202133-52213243 (-)
AKR/J ENSMUSG00220028102
 protein coding gene Chr14:51549561-51560650 (-)
BALB/cJ ENSMUSG00180032203
 protein coding gene Chr14:51824023-51835134 (-)
C3H/HeJ ENSMUSG00175031104
 protein coding gene Chr14:53557198-53568295 (-)
C57BL/6NJ ENSMUSG00215024382
 protein coding gene Chr14:51747599-51758706 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019402
 protein coding gene Chr14:54337839-54349484 (-)
CAST/EiJ ENSTCUG00005038267
 protein coding gene Chr14:53487779-53498818 (-)
CBA/J ENSMUSG00210033358
 protein coding gene Chr14:52190044-52201153 (-)
DBA/2J ENSMUSG00185029183
 protein coding gene Chr14:57355002-57366097 (-)
FVB/NJ ENSMUSG00205029112
 protein coding gene Chr14:51707507-51718616 (-)
JF1/MsJ ENSUMUG00000029756
 protein coding gene Chr14:68550492-68561771 (-)
LP/J ENSMUSG00230032627
 protein coding gene Chr14:69384562-69395658 (-)
NOD/ShiLtJ ENSMUSG00190039506
 protein coding gene Chr14:51984738-51995849 (-)
NZO/HlLtJ ENSMUSG00225046366
 protein coding gene Chr14:59726868-59737973 (-)
PWK/PhJ ENSLUMG00010030645
 protein coding gene Chr14:51433906-51445154 (-)
SPRET/EiJ ENSMSPG00010029703
 protein coding gene Chr14:54919781-54930937 (-)
WSB/EiJ ENSIUOG00005037156
 protein coding gene Chr14:51431045-51442147 (-)



Homology
more
  • Human Ortholog
    NEIL2, nei like DNA glycosylase 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEIL2, nei like DNA glycosylase 2
  • Synonyms
    NEH2, NEI2
  • Links
    NCBI Gene ID: 252969
    UniProt: Q969S2

  • Chr Location
    8p23.1; chr8:11769639-11787345 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased age-related DNA damage, loss of telomeres and increased induced lung inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    2
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035121 Ensembl Gene Model | MGI Sequence Detail 11414 C57BL/6J ±  kb
    transcript ENSMUST00000038229 Ensembl | MGI Sequence Detail 1932 Not Applicable  
    polypeptide ENSMUSP00000045200 Ensembl | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6
      Antibodies 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:96949 Conlon KA, et al., The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. DNA Repair (Amst). 2005 Apr 4;4(4):419-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory