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Layn Gene Detail
Summary
  • Symbol
    Layn
  • Name
    layilin
  • Synonyms
    E030012M19Rik, LOC244864
  • Feature Type
    protein coding gene
  • IDs
    MGI:2685357
    NCBI Gene: 244864
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50966323-50988501 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 27.79 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    691 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2685357
 protein coding gene Chr9:50965940-50988501 (-)
129S1/SvImJ ENSMUSG00200018001
 protein coding gene Chr9:48136673-48158875 (-)
A/J ENSMUSG00195020233
 protein coding gene Chr9:47827671-47850144 (-)
AKR/J ENSMUSG00220035859
 protein coding gene Chr9:47911089-47933555 (-)
BALB/cJ ENSMUSG00180029972
 protein coding gene Chr9:47939069-47961532 (-)
C3H/HeJ ENSMUSG00175014980
 protein coding gene Chr9:47951078-47973546 (-)
C57BL/6NJ ENSMUSG00215020138
 protein coding gene Chr9:47893403-47915862 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032201
 protein coding gene Chr9:47910535-47931903 (-)
CAST/EiJ ENSTCUG00005015010
 protein coding gene Chr9:47852456-47874817 (-)
CBA/J ENSMUSG00210016454
 protein coding gene Chr9:48016948-48039422 (-)
DBA/2J ENSMUSG00185009794
 protein coding gene Chr9:48065521-48087993 (-)
FVB/NJ ENSMUSG00205036013
 protein coding gene Chr9:48285544-48308005 (-)
JF1/MsJ ENSUMUG00000034234
 protein coding gene Chr9:48108222-48130503 (-)
LP/J ENSMUSG00230041351
 protein coding gene Chr9:48352465-48374671 (-)
NOD/ShiLtJ ENSMUSG00190018702
 protein coding gene Chr9:48145603-48168067 (-)
NZO/HlLtJ ENSMUSG00225043032
 protein coding gene Chr9:48321376-48343834 (-)
PWK/PhJ ENSLUMG00010020440
 protein coding gene Chr9:48078734-48101189 (-)
SPRET/EiJ ENSMSPG00010009286
 protein coding gene Chr9:48897824-48920456 (-)
WSB/EiJ ENSIUOG00005018114
 protein coding gene Chr9:47552715-47575199 (-)



Homology
more
  • Human Ortholog
    LAYN, layilin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAYN, layilin
  • Links
    NCBI Gene ID: 143903
    UniProt: Q6UX15

  • Chr Location
    11q23.1; chr11:111540280-111561745 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display enhance tumor growth when translated with tumor cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    616
  • Tissues
    6
  • cDNA Data
    7
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 244864 NCBI Gene Model | MGI Sequence Detail 22179 C57BL/6J ±  kb
transcript NM_001033534 RefSeq | MGI Sequence Detail 1786 C57BL/6  
polypeptide Q8C351 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:113797 Borowsky ML, et al., Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles. J Cell Biol. 1998 Oct 19;143(2):429-42
  • Latest
    J:375540 Gouirand V, et al., Layilin regulates Treg motility and suppressive capacity in skin. Elife. 2025 Jul 21;14
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory