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Man1b1 Gene Detail
Summary
  • Symbol
    Man1b1
  • Name
    mannosidase, alpha, class 1B, member 1
  • Synonyms
    E430019H13Rik, LOC227619, MANA-ER
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684954
    NCBI Gene: 227619
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25222742-25242225 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.17 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684954
 protein coding gene Chr2:25222350-25242225 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025439
 protein coding gene Chr2:23206086-23229841 (+)
A/J MGP_AJ_G0025416
 protein coding gene Chr2:22314720-22335122 (+)
AKR/J MGP_AKRJ_G0025386
 protein coding gene Chr2:23061441-23083574 (+)
BALB/cJ MGP_BALBcJ_G0025412
 protein coding gene Chr2:22425230-22446092 (+)
C3H/HeJ MGP_C3HHeJ_G0025173
 protein coding gene Chr2:22988485-23014831 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025856
 protein coding gene Chr2:23948383-23974247 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023267
 protein coding gene Chr2:21226978-21246725 (+)
CAST/EiJ MGP_CASTEiJ_G0024636
 protein coding gene Chr2:22870806-22893273 (+)
CBA/J MGP_CBAJ_G0025151
 protein coding gene Chr2:24774458-24801145 (+)
DBA/2J MGP_DBA2J_G0025284
 protein coding gene Chr2:22154980-22174611 (+)
FVB/NJ MGP_FVBNJ_G0025246
 protein coding gene Chr2:21896197-21916402 (+)
LP/J MGP_LPJ_G0025370
 protein coding gene Chr2:23151028-23171785 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025277
 protein coding gene Chr2:24978239-24999742 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025915
 protein coding gene Chr2:23006797-23028384 (+)
PWK/PhJ MGP_PWKPhJ_G0024384
 protein coding gene Chr2:21970162-21990688 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024184
 protein coding gene Chr2:23157115-23177673 (+)
WSB/EiJ MGP_WSBEiJ_G0024705
 protein coding gene Chr2:23077718-23098300 (+)



Homology
more
  • Human Ortholog
    MAN1B1, mannosidase alpha class 1B member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAN1B1, mannosidase alpha class 1B member 1
  • Synonyms
    ERMAN1, ERManI, MANA-ER, MRT15
  • Links
    NCBI Gene ID: 11253
    neXtProt AC: NX_Q9UKM7
    UniProt: Q9UKM7

  • Chr Location
    9q34.3; chr9:137086857-137109189 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MAN1B1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    85
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227619 NCBI Gene Model | MGI Sequence Detail 19484 C57BL/6J ±  kb
    transcript NM_001029983 RefSeq | MGI Sequence Detail 3748 C57BL/6  
    polypeptide A2AJ15 UniProt | EBI | MGI Sequence Detail 658 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 86
      cDNA 85
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory