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Arap2 Gene Detail
Summary
  • Symbol
    Arap2
  • Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
  • Synonyms
    Centd1, mKIAA0580
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684416
    NCBI Gene: 212285
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:62759788-62923502 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 32.04 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4487 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684416
 protein coding gene Chr5:62759788-62923874 (-)
129S1/SvImJ ENSMUSG00200000053
 protein coding gene Chr5:58372356-58537281 (-)
A/J ENSMUSG00195000261
 protein coding gene Chr5:57726704-57891671 (-)
AKR/J ENSMUSG00220006885
 protein coding gene Chr5:57854498-58019463 (-)
BALB/cJ ENSMUSG00180006052
 protein coding gene Chr5:57489565-57654420 (-)
C3H/HeJ ENSMUSG00175001712
 protein coding gene Chr5:59525104-59689951 (-)
C57BL/6NJ ENSMUSG00215002760
 protein coding gene Chr5:58303987-58468920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027231
 protein coding gene Chr5:55992504-56157152 (-)
CAST/EiJ ENSTCUG00005000289
 protein coding gene Chr5:57446195-57611129 (-)
CBA/J ENSMUSG00210000057
 protein coding gene Chr5:58452231-58617186 (-)
DBA/2J ENSMUSG00185000068
 protein coding gene Chr5:60306272-60470854 (-)
FVB/NJ ENSMUSG00205009503
 protein coding gene Chr5:57262351-57427306 (-)
JF1/MsJ ENSUMUG00000009343
 protein coding gene Chr5:64819729-64988473 (-)
LP/J ENSMUSG00230005483
 protein coding gene Chr5:64988243-65153149 (-)
NOD/ShiLtJ ENSMUSG00190000183
 protein coding gene Chr5:57419664-57584645 (-)
NZO/HlLtJ ENSMUSG00225002424
 protein coding gene Chr5:70110275-70275164 (-)
PWK/PhJ ENSLUMG00010003991
 protein coding gene Chr5:57457677-57623677 (-)
SPRET/EiJ ENSMSPG00010003918
 protein coding gene Chr5:59219509-59386204 (-)
WSB/EiJ ENSIUOG00005000055
 protein coding gene Chr5:60386612-60551314 (-)



Homology
more
  • Human Ortholog
    ARAP2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARAP2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
  • Synonyms
    CENTD1, PARX
  • Links
    NCBI Gene ID: 116984
    UniProt: Q8WZ64

  • Chr Location
    4p14; chr4:35948221-36244784 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    46
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037999 Ensembl Gene Model | MGI Sequence Detail 163715 C57BL/6J ±  kb
transcript ENSMUST00000076623 Ensembl | MGI Sequence Detail 7306 Not Applicable  
polypeptide ENSMUSP00000075924 Ensembl | MGI Sequence Detail 1703 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004194 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
    (term hierarchy)
  • InterPro Domains
    IPR037858 ARAP, RhoGAP domain
    IPR038508 ArfGAP domain superfamily
    IPR037278 ARFGAP/RecO-like, zinc finger superfamily
    IPR052227 Arf-GAP with Rho-GAP, ANK repeat and PH domain-containing protein
    IPR001164 Arf GTPase activating protein
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR000159 Ras-associating domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
  • GlyGen
    Q8BZ05 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 4
Other
Accession IDs
less
MGI:2684994
References
more
  • Summaries
    All 56
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 27
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory