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Atg4c Gene Detail
Summary
  • Symbol
    Atg4c
  • Name
    autophagy related 4C, cysteine peptidase
  • Synonyms
    Apg4c, Apg4-C, Autl1, autophagin 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2651854
    NCBI Gene: 242557
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:99082171-99148024 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 45.61 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    873 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2651854
 protein coding gene Chr4:99077181-99185495 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028479
 protein coding gene Chr4:99419583-99486819 (+)
A/J MGP_AJ_G0028442
 protein coding gene Chr4:95965947-96030975 (+)
AKR/J MGP_AKRJ_G0028389
 protein coding gene Chr4:98289344-98351870 (+)
BALB/cJ MGP_BALBcJ_G0028460
 protein coding gene Chr4:96219160-96286213 (+)
C3H/HeJ MGP_C3HHeJ_G0028173
 protein coding gene Chr4:99095583-99160045 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028899
 protein coding gene Chr4:103183748-103248241 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026191
 protein coding gene Chr4:91349734-91410644 (+)
CAST/EiJ MGP_CASTEiJ_G0027613
 protein coding gene Chr4:96875250-96952703 (+)
CBA/J MGP_CBAJ_G0028142
 protein coding gene Chr4:106360077-106431355 (+)
DBA/2J MGP_DBA2J_G0028292
 protein coding gene Chr4:95691739-95754257 (+)
FVB/NJ MGP_FVBNJ_G0028259
 protein coding gene Chr4:94535347-94597354 (+)
LP/J MGP_LPJ_G0028392
 protein coding gene Chr4:99732287-99799685 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028287
 protein coding gene Chr4:112088301-112156841 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028937
 protein coding gene Chr4:98530334-98594232 (+)
PWK/PhJ MGP_PWKPhJ_G0027338
 protein coding gene Chr4:93838194-93902028 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027159
 protein coding gene Chr4:95978164-96045482 (+)
WSB/EiJ MGP_WSBEiJ_G0027691
 protein coding gene Chr4:98672885-98743270 (+)



Homology
more
  • Human Ortholog
    ATG4C, autophagy related 4C cysteine peptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATG4C, autophagy related 4C cysteine peptidase
  • Synonyms
    APG4C, APG4-C, AUTL1, AUTL3, HsAPG4C
  • Links
    NCBI Gene ID: 84938
    neXtProt AC: NX_Q96DT6
    UniProt: Q96DT6

  • Chr Location
    1p31.3; chr1:62784132-62865516 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a higher incidence of chemically-induced fibrosarcomas, and exhibit both a significant reduction of autophagic activity in the diaphragm muscle as well as decreased locomotor activity after prolonged starvation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    30
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028550 Ensembl Gene Model | MGI Sequence Detail 65854 C57BL/6J ±  kb
transcript ENSMUST00000030279 Ensembl | MGI Sequence Detail 3178 Not Applicable  
polypeptide ENSMUSP00000030279 Ensembl | MGI Sequence Detail 458 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:81439 Marino G, et al., Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem. 2003 Feb 7;278(6):3671-8
  • Latest
    J:341370 Tamargo-Gomez I, et al., Analysis of ATG4C function in vivo. Autophagy. 2023 Nov;19(11):2912-2933
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory