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Cdk10 Gene Detail
Summary
  • Symbol
    Cdk10
  • Name
    cyclin dependent kinase 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448549
    NCBI Gene: 234854
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123951581-123958989 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448549
 protein coding gene Chr8:123951580-123958995 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034247
 protein coding gene Chr8:126825445-126832860 (+)
A/J MGP_AJ_G0034227
 protein coding gene Chr8:121571414-121579345 (+)
AKR/J MGP_AKRJ_G0034154
 protein coding gene Chr8:125104132-125108878 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0033931
 protein coding gene Chr8:125804632-125812719 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034740
 protein coding gene Chr8:131067886-131077301 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031682
 protein coding gene Chr8:114392306-114399670 (+)
CAST/EiJ MGP_CASTEiJ_G0033259
 protein coding gene Chr8:125885717-125893484 (+)
CBA/J MGP_CBAJ_G0033904
 protein coding gene Chr8:135874699-135886778 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0034004
 protein coding gene Chr8:119913189-119924480 (+)
LP/J MGP_LPJ_G0034150
 protein coding gene Chr8:126956560-126966517 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034051
 protein coding gene Chr8:138020694-138028661 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034759
 protein coding gene Chr8:125315125-125326388 (+)
PWK/PhJ MGP_PWKPhJ_G0032960
 protein coding gene Chr8:120582490-120589439 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032800
 protein coding gene Chr8:124034314-124038651 (+)
WSB/EiJ MGP_WSBEiJ_G0033375
 protein coding gene Chr8:126049847-126058946 (+)



Homology
more
  • Human Ortholog
    CDK10, cyclin dependent kinase 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK10, cyclin dependent kinase 10
  • Synonyms
    ALSAS, PISSLRE
  • Links
    NCBI Gene ID: 8558
    neXtProt AC: NX_Q15131
    UniProt: Q15131

  • Chr Location
    16q24.3; chr16:89680737-89696354 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severe growth retardation, neonatal lethality, spine malformations and defects in lung, heart, liver and spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    70
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033862 Ensembl Gene Model | MGI Sequence Detail 7409 C57BL/6J ±  kb
    transcript ENSMUST00000036880 Ensembl | MGI Sequence Detail 1642 Not Applicable  
    polypeptide ENSMUSP00000045527 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 70

      Microarray probesets 4
    References
    more
    • Summaries
      All 31
      Gene Ontology 9
      Phenotypes 3
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:262333 Windpassinger C, et al., CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays. Am J Hum Genet. 2017 Sep 7;101(3):391-403
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory