Farp1 MGI Mouse Gene Detail - MGI:2446173 - FERM, ARH/RhoGEF and pleckstrin domain protein 1

Symbol

Farp1
Name

FERM, ARH/RhoGEF and pleckstrin domain protein 1
Synonyms

Cdep

Feature Type

protein coding gene
IDs

MGI:2446173
NCBI Gene: 223254
Alliance

genome feature page
Transcription Start Sites

18 TSS

Sequence Map

Chr14:121272612-121521156 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 64.86 cM
Mapping Data

1 experiment

SNPs within 2kb

8166 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2446173	protein coding gene	Chr14:121272563-121521156 (+)
129S1/SvImJ	ENSMUSG00200023670	protein coding gene	Chr14:110166469-110414873 (+)
A/J	ENSMUSG00195030567	protein coding gene	Chr14:109909727-110156634 (+)
AKR/J	ENSMUSG00220007529	protein coding gene	Chr14:109718796-109965689 (+)
BALB/cJ	ENSMUSG00180025942	protein coding gene	Chr14:109401592-109648510 (+)
C3H/HeJ	ENSMUSG00175005712	protein coding gene	Chr14:111325746-111572622 (+)
C57BL/6NJ	ENSMUSG00215021931	protein coding gene	Chr14:109540264-109788802 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019604	protein coding gene	Chr14:110135967-110382521 (+)
CAST/EiJ	ENSTCUG00005006969	protein coding gene	Chr14:110935502-111182175 (+)
CBA/J	ENSMUSG00210026858	protein coding gene	Chr14:110286823-110533684 (+)
DBA/2J	ENSMUSG00185013842	protein coding gene	Chr14:115444086-115689878 (+)
FVB/NJ	ENSMUSG00205007622	protein coding gene	Chr14:108997714-109246142 (+)
JF1/MsJ	ENSUMUG00000024370	protein coding gene	Chr14:126450425-126684659 (+)
LP/J	ENSMUSG00230011534	protein coding gene	Chr14:127415542-127661328 (+)
NOD/ShiLtJ	ENSMUSG00190024997	protein coding gene	Chr14:110122861-110371249 (+)
NZO/HlLtJ	ENSMUSG00225029062	protein coding gene	Chr14:117485826-117740589 (+)
PWK/PhJ	ENSLUMG00010028446	protein coding gene	Chr14:109374256-109617460 (+)
SPRET/EiJ	ENSMSPG00010013952	protein coding gene	Chr14:113660995-113901896 (+)
WSB/EiJ	ENSIUOG00005029517	protein coding gene	Chr14:109313738-109562440 (+)

Human Ortholog

FARP1, FERM, ARH/RhoGEF and pleckstrin domain protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FARP1, FERM, ARH/RhoGEF and pleckstrin domain protein 1
Synonyms

CDEP, FARP1-IT1, GLCC1, PLEKHC2, PPP1R75
Links

HGNC:3591

NCBI Gene ID: 10160

UniProt: Q9Y4F1
Chr Location

13q32.2; chr13:98142165-98455176 (+) GRCh38

MGI Vertebrate Homology

Farp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FARP1
Gene Tree

Farp1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

2
Targeted

3
Genomic Mutations

1 involving Farp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

43
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

643
Tissues

32
cDNA Data

143
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FARP1

Xenbase farp1

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All Sequences

89
RefSeq

16
UniProt

10
CCDS

CCDS37015.1

Ensembl

ENSMUSG00000025555 (Evidence)
NCBI Gene

223254

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025555	Ensembl Gene Model \| MGI Sequence Detail	248545	C57BL/6J	± kb
transcript	ENSMUST00000026635	Ensembl \| MGI Sequence Detail	4885	Not Applicable
polypeptide	ENSMUSP00000026635	Ensembl \| MGI Sequence Detail	1048	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000007343 FERM, ARHGEF and pleckstrin domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR019749 Band 4.1 domain

IPR035899 Dbl homology (DH) domain superfamily

IPR000219 Dbl homology domain

IPR000798 Ezrin/radixin/moesin-like

IPR041788 FARP1/FARP2/FRMD7, FERM domain C-lobe

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR014847 FERM adjacent

IPR019748 FERM central domain

IPR019747 FERM conserved site

IPR018980 FERM, C-terminal PH-like domain

IPR000299 FERM domain

IPR018979 FERM, N-terminal

IPR035963 FERM superfamily, second domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR051835 RAC1-specific guanine nucleotide exchange factor

IPR029071 Ubiquitin-like domain superfamily
GlyGen

F8VPU2 3 sites, 1 O-linked glycan (1 site)

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All nucleic 144

cDNA 143

Other 1

Microarray probesets 4

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MGI:2145808

Summaries

All 45

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 13
Earliest

J:86639 Luo ZG, et al., Implication of geranylgeranyltransferase I in synapse formation. Neuron. 2003 Nov 13;40(4):703-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Farp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127267	Chr14:121272568-121272598 (+)	-29 bp
Tssr127268	Chr14:121272606-121272620 (+)	1 bp
Tssr127269	Chr14:121272848-121272859 (+)	242 bp
Tssr127270	Chr14:121272875-121272891 (+)	271 bp
Tssr127271	Chr14:121272896-121272912 (+)	292 bp
Tssr127272	Chr14:121272921-121272932 (+)	315 bp
Tssr127273	Chr14:121272950-121272987 (+)	357 bp
Tssr127274	Chr14:121273094-121273105 (+)	488 bp
Tssr127275	Chr14:121273171-121273214 (+)	581 bp
Tssr127276	Chr14:121273217-121273238 (+)	616 bp
Tssr127277	Chr14:121295045-121295049 (+)	22,435 bp
Tssr4533	Chr14:121300618-121300625 (+)	28,010 bp
Tssr127278	Chr14:121344883-121344884 (+)	72,272 bp
Tssr127279	Chr14:121384214-121384219 (+)	111,605 bp
Tssr127280	Chr14:121468347-121468351 (+)	195,737 bp
Tssr127281	Chr14:121477089-121477096 (+)	204,481 bp
Tssr127282	Chr14:121477137-121477149 (+)	204,531 bp
Tssr127283	Chr14:121477150-121477160 (+)	204,543 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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