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Dpp9 Gene Detail
Summary
  • Symbol
    Dpp9
  • Name
    dipeptidylpeptidase 9
  • Synonyms
    6430584G11Rik, DPRP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443967
    NCBI Gene: 224897
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56493807-56525905 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    743 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443967
 protein coding gene Chr17:56493674-56525927 (-)
129S1/SvImJ ENSMUSG00200016619
 protein coding gene Chr17:51768545-51801046 (-)
A/J ENSMUSG00195006989
 protein coding gene Chr17:53155952-53188479 (-)
AKR/J ENSMUSG00220012475
 protein coding gene Chr17:52205332-52237860 (-)
BALB/cJ ENSMUSG00180005648
 protein coding gene Chr17:52913595-52946119 (-)
C3H/HeJ ENSMUSG00175006692
 protein coding gene Chr17:52229659-52262191 (-)
C57BL/6NJ ENSMUSG00215008842
 protein coding gene Chr17:51843780-51876293 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021770
 protein coding gene Chr17:52773545-52806771 (-)
CAST/EiJ ENSTCUG00005018174
 protein coding gene Chr17:52961454-52993959 (-)
CBA/J ENSMUSG00210027368
 protein coding gene Chr17:51996723-52029250 (-)
DBA/2J ENSMUSG00185008950
 protein coding gene Chr17:54866577-54899090 (-)
FVB/NJ ENSMUSG00205006531
 protein coding gene Chr17:52544221-52576726 (-)
JF1/MsJ ENSUMUG00000017602
 protein coding gene Chr17:54544766-54577339 (-)
LP/J ENSMUSG00230024842
 protein coding gene Chr17:55845963-55878456 (-)
NOD/ShiLtJ ENSMUSG00190009487
 protein coding gene Chr17:51999428-52031939 (-)
NZO/HlLtJ ENSMUSG00225041664
 protein coding gene Chr17:58129788-58162314 (-)
PWK/PhJ ENSLUMG00010009264
 protein coding gene Chr17:51804060-51836661 (-)
SPRET/EiJ ENSMSPG00010005157
 protein coding gene Chr17:52120331-52152697 (-)
WSB/EiJ ENSIUOG00005022534
 protein coding gene Chr17:52906050-52938587 (-)



Homology
more
  • Human Ortholog
    DPP9, dipeptidyl peptidase 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPP9, dipeptidyl peptidase 9
  • Synonyms
    DP9, DPLP9, DPP IX, DPRP-2, DPRP2, HATIS, IMD111
  • Links
    NCBI Gene ID: 91039
    UniProt: Q86TI2

  • Chr Location
    19p13.3; chr19:4674341-4724673 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DPP9 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 5 alleles in 4 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display partial neonatal lethality and complete lethality at preweaning stages with defects suckling due to undeveveloped tongue muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    637
  • Tissues
    22
  • cDNA Data
    72
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001229 Ensembl Gene Model | MGI Sequence Detail 32099 C57BL/6J ±  kb
    transcript ENSMUST00000038794 Ensembl | MGI Sequence Detail 3374 Not Applicable  
    polypeptide ENSMUSP00000046604 Ensembl | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 72
      Primer pair 1
      Other 2
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:365946 Huang JC, et al., Dipeptidyl peptidase 9 (DPP9) depletion from hepatocytes in experimental primary liver cancer. Biochim Biophys Acta Mol Basis Dis. 2025 Jun;1871(5):167819
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory