About   Help   FAQ
Dlgap2 Gene Detail
Summary
  • Symbol
    Dlgap2
  • Name
    DLG associated protein 2
  • Synonyms
    6430596N04Rik, DAP2, PSD-95/SAP90-binding protein 2, SAP90/PSD-95-associated protein 2, Sapap2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443181
    NCBI Gene: 244310
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:14145865-14897680 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 6.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7670 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443181
 protein coding gene Chr8:14145793-14903426 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033395
 protein coding gene Chr8:11477148-12268583 (+)
A/J MGP_AJ_G0033376
 protein coding gene Chr8:11066944-11829110 (+)
AKR/J MGP_AKRJ_G0033306
 protein coding gene Chr8:11341960-12119822 (+)
BALB/cJ MGP_BALBcJ_G0033376
 protein coding gene Chr8:11167559-11913506 (+)
C3H/HeJ MGP_C3HHeJ_G0033089
 protein coding gene Chr8:11584223-12358538 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033888
 protein coding gene Chr8:11857758-12640304 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030854
 protein coding gene Chr8:10771954-10898957 (+)
CAST/EiJ MGP_CASTEiJ_G0032411
 protein coding gene Chr8:11372432-12173328 (+)
CBA/J MGP_CBAJ_G0033062
 protein coding gene Chr8:12351076-13181885 (+)
DBA/2J MGP_DBA2J_G0033216
 protein coding gene Chr8:11005191-11752260 (+)
FVB/NJ MGP_FVBNJ_G0033164
 protein coding gene Chr8:11021105-11777186 (+)
LP/J MGP_LPJ_G0033309
 protein coding gene Chr8:11460348-12241892 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033201
 protein coding gene Chr8:12591002-13389724 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033905
 protein coding gene Chr8:11445913-12224762 (+)
PWK/PhJ MGP_PWKPhJ_G0032124
 protein coding gene Chr8:11065515-11814927 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031965
 protein coding gene Chr8:11313213-12096333 (+)
WSB/EiJ MGP_WSBEiJ_G0032527
 protein coding gene Chr8:11465100-12243775 (+)



Homology
more
  • Human Ortholog
    DLGAP2, DLG associated protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLGAP2, DLG associated protein 2
  • Synonyms
    C8orf68, DAP2, ERICH1-AS1, SAPAP2
  • Links
    NCBI Gene ID: 9228
    UniProt: Q9P1A6

  • Chr Location
    8p23.3; chr8:737628-1708476 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit novelty-induced hyperactivity, increased aggression, impaired reverse learning, decreased dendritic spine density, synaptopathies, reduced mESPC amplitude and enhanced paired-pulse ratio.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    10
  • cDNA Data
    8
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047495 Ensembl Gene Model | MGI Sequence Detail 751816 C57BL/6J ±  kb
transcript ENSMUST00000152652 Ensembl | MGI Sequence Detail 3842 Not Applicable  
polypeptide ENSMUSP00000123078 Ensembl | MGI Sequence Detail 1060 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:342803 Horner AE, et al., Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2. Genes Brain Behav. 2021 Jan;20(1):e12723
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory