Pld5 MGI Mouse Gene Detail - MGI:2442056 - phospholipase D family member 5

Symbol

Pld5
Name

phospholipase D family member 5
Synonyms

B230365F16Rik

Feature Type

protein coding gene
IDs

MGI:2442056
NCBI Gene: 319455
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:175789872-176102878 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 81.90 cM
Mapping Data

1 experiment

SNPs within 2kb

10741 from dbSNP Build 142
Strain Annotations

31

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442056	protein coding gene	Chr1:175789867-176109078 (-)
129S1/SvImJ	ENSMUSGG00200054925	protein coding gene	Chr1:173547340-173805783 (-)
129S1/SvImJ	ENSMUSG00200021612	protein coding gene	Chr1:173852848-173867378 (-)
A/J	ENSMUSG00195042405	protein coding gene	Chr1:173268126-173282644 (-)
A/J	ENSMUSGG00195055115	protein coding gene	Chr1:172963915-173221095 (-)
AKR/J	ENSMUSGG00220054456	protein coding gene	Chr1:172554195-172819789 (-)
AKR/J	ENSMUSG00220030257	protein coding gene	Chr1:172866480-172880985 (-)
BALB/cJ	ENSMUSG00180035461	protein coding gene	Chr1:173503831-173518359 (-)
BALB/cJ	ENSMUSGG00180055293	protein coding gene	Chr1:173198286-173456763 (-)
C3H/HeJ	ENSMUSGG00175054774	protein coding gene	Chr1:173374448-173632889 (-)
C3H/HeJ	ENSMUSG00175036687	protein coding gene	Chr1:173679956-173694482 (-)
C57BL/6NJ	ENSMUSG00215042618	protein coding gene	Chr1:173049483-173064021 (-)
C57BL/6NJ	ENSMUSGG00215055740	protein coding gene	Chr1:172752427-173002672 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014950	protein coding gene	Chr1:166050055-166373974 (-)
CAST/EiJ	ENSTCUGG00005053871	protein coding gene	Chr1:171263709-171522128 (-)
CBA/J	ENSMUSGG00210054596	protein coding gene	Chr1:173009646-173271866 (-)
CBA/J	ENSMUSG00210037936	protein coding gene	Chr1:173318664-173333200 (-)
DBA/2J	ENSMUSGG00185057560	protein coding gene	Chr1:177628388-177890635 (-)
DBA/2J	ENSMUSG00185027985	protein coding gene	Chr1:177937427-177951967 (-)
FVB/NJ	ENSMUSGG00205054095	protein coding gene	Chr1:172121886-172378224 (-)
FVB/NJ	ENSMUSG00205019835	protein coding gene	Chr1:172424900-172439412 (-)
JF1/MsJ	ENSUMUGG00000058371	protein coding gene	Chr1:176465179-176737203 (-)
LP/J	ENSMUSGG00230055557	protein coding gene	Chr1:177213493-177471911 (-)
LP/J	ENSMUSG00230032460	protein coding gene	Chr1:177518975-177533499 (-)
NOD/ShiLtJ	ENSMUSGG00190054957	protein coding gene	Chr1:173048996-173307423 (-)
NOD/ShiLtJ	ENSMUSG00190034131	protein coding gene	Chr1:173354488-173369012 (-)
NZO/HlLtJ	ENSMUSG00225004370	protein coding gene	Chr1:181105689-181119921 (-)
NZO/HlLtJ	ENSMUSGG00225055299	protein coding gene	Chr1:180781032-181049608 (-)
PWK/PhJ	ENSLUMGG00010053944	protein coding gene	Chr1:171763986-172021104 (-)
SPRET/EiJ	ENSMSPGG00010052291	protein coding gene	Chr1:175383083-175644848 (-)
WSB/EiJ	ENSIUOGG00005053860	protein coding gene	Chr1:172121763-172372877 (-)

Human Ortholog

PLD5, phospholipase D family member 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLD5, phospholipase D family member 5
Synonyms

PLDC
Links

HGNC:26879

NCBI Gene ID: 200150

UniProt: Q8N7P1
Chr Location

1q43; chr1:242082986-242530546 (-) GRCh38

MGI Vertebrate Homology

Pld5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLD5
Gene Tree

Pld5

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

2
Gene trapped

1
Targeted

2
Genomic Mutations

2 involving Pld5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available

No abnormal phenotype was observed in a high-throughput screen, nor in a pathology assessment.

less

All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

87
RefSeq

30
UniProt

5
CCDS

CCDS15552.1, CCDS56660.1

Ensembl

ENSMUSG00000055214 (Evidence)
NCBI Gene

319455

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055214	Ensembl Gene Model \| MGI Sequence Detail	313007	C57BL/6J	± kb
transcript	ENSMUST00000065967	Ensembl \| MGI Sequence Detail	3557	Not Applicable
polypeptide	ENSMUSP00000069326	Ensembl \| MGI Sequence Detail	536	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000012847 inactive phospholipase D5

(term hierarchy)
InterPro Domains

IPR050874 Diverse function phospholipase D-related protein

IPR001736 Phospholipase D/Transphosphatidylase

IPR032803 PLD3/4-like, PLD-like domain
GlyGen

Q3UNN8 7 sites, 6 N-linked glycans (6 sites)

less

All nucleic 10

cDNA 10

Microarray probesets 1

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 10
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pld5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr15411	Chr1:176102849-176102874 (-)	16 bp
Tssr15410	Chr1:176041607-176041613 (-)	61,268 bp
Tssr15409	Chr1:176041581-176041590 (-)	61,292 bp
Tssr15408	Chr1:176041540-176041543 (-)	61,336 bp
Tssr15407	Chr1:176041524-176041533 (-)	61,349 bp
Tssr15406	Chr1:176041500-176041509 (-)	61,373 bp
Tssr15405	Chr1:176041335-176041345 (-)	61,538 bp
Tssr15404	Chr1:176041306-176041313 (-)	61,568 bp
Tssr15403	Chr1:176041270-176041284 (-)	61,601 bp
Tssr15402	Chr1:176041239-176041250 (-)	61,633 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24