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Ppp2r5d Gene Detail
Summary
  • Symbol
    Ppp2r5d
  • Name
    protein phosphatase 2, regulatory subunit B', delta
  • Synonyms
    B'delta, TEG-271, Tex271
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388481
    NCBI Gene: 21770
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:46993917-47015952 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    591 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388481
 protein coding gene Chr17:46993917-47016037 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023828
 protein coding gene Chr17:47763829-47790601 (-)
A/J MGP_AJ_G0023786
 protein coding gene Chr17:46616537-46638365 (-)
AKR/J MGP_AKRJ_G0023757
 protein coding gene Chr17:46963331-46986280 (-)
BALB/cJ MGP_BALBcJ_G0023790
 protein coding gene Chr17:46516751-46538828 (-)
C3H/HeJ MGP_C3HHeJ_G0023553
 protein coding gene Chr17:47707323-47729820 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024233
 protein coding gene Chr17:49812956-49840887 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021683
 protein coding gene Chr17:43397053-43419480 (-)
CAST/EiJ MGP_CASTEiJ_G0023034
 protein coding gene Chr17:47792473-47816569 (-)
CBA/J MGP_CBAJ_G0023530
 protein coding gene Chr17:51611989-51636468 (-)
DBA/2J MGP_DBA2J_G0023656
 protein coding gene Chr17:45385916-45408189 (-)
FVB/NJ MGP_FVBNJ_G0023623
 protein coding gene Chr17:45008941-45030718 (-)
LP/J MGP_LPJ_G0023737
 protein coding gene Chr17:48441995-48468648 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023652
 protein coding gene Chr17:51151089-51174572 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024278
 protein coding gene Chr17:47315160-47337015 (-)
PWK/PhJ MGP_PWKPhJ_G0022779
 protein coding gene Chr17:44726075-44748704 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022595
 protein coding gene Chr17:44187153-44218119 (-)
WSB/EiJ MGP_WSBEiJ_G0023100
 protein coding gene Chr17:47869864-47893475 (-)



Homology
more
  • Human Ortholog
    PPP2R5D, protein phosphatase 2 regulatory subunit B'delta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R5D, protein phosphatase 2 regulatory subunit B'delta
  • Synonyms
    B56D, B56delta, HJS1, MRD35
  • Links
    NCBI Gene ID: 5528
    UniProt: Q14738

  • Chr Location
    6p21.1; chr6:42984538-43012346 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPP2R5D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 5 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trap allele exhibit lethality, while heterozygous mice display decreased prepulse inhibition. Mice homozygous for a targeted knock-out allele exhibit decreased thermal nociception threshold, impaired coordination, and increased latency to removing an adhesive sticker.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    22
  • cDNA Data
    6
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21770 NCBI Gene Model | MGI Sequence Detail 22036 C57BL/6J ±  kb
transcript NM_001357684 RefSeq | MGI Sequence Detail 2967 ZRU/MplStud  
polypeptide NP_001344613 RefSeq | MGI Sequence Detail 595 ZRU/MplStud  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR002554 Protein phosphatase 2A, regulatory B subunit, B56
  • GlyGen
    Q7TNL5 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1096565
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Phenotypes 14
  • Earliest
    J:35463 Lopez-Fernandez LA, et al., Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. Mamm Genome. 1996 Sep;7(9):698-700
  • Latest
    J:339909 Domenech Omella J, et al., A Novel Mouse Model of Combined Hepatocellular-Cholangiocarcinoma Induced by Diethylnitrosamine and Loss of Ppp2r5d. Cancers (Basel). 2023 Aug 21;15(16)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory