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Fermt2 Gene Detail
Summary
  • Symbol
    Fermt2
  • Name
    fermitin family member 2
  • Synonyms
    Kindlin-2, Mig2, Plekhc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385001
    NCBI Gene: 218952
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:45696252-45767575 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.97 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2015 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385001
 protein coding gene Chr14:45696252-45767767 (-)
129S1/SvImJ ENSMUSG00200014654
 protein coding gene Chr14:34496581-34505128 (-)
129S1/SvImJ ENSMUSGG00200054460
 protein coding gene Chr14:34531940-34557055 (-)
A/J ENSMUSG00195023923
 protein coding gene Chr14:34725204-34733753 (-)
A/J ENSMUSGG00195054954
 protein coding gene Chr14:34760566-34785683 (-)
AKR/J ENSMUSG00220029992
 protein coding gene Chr14:34084796-34093343 (-)
AKR/J ENSMUSGG00220054427
 protein coding gene Chr14:34120154-34145270 (-)
BALB/cJ ENSMUSG00180036548
 protein coding gene Chr14:34328886-34337434 (-)
BALB/cJ ENSMUSGG00180055072
 protein coding gene Chr14:34364247-34389367 (-)
C3H/HeJ ENSMUSG00175025771
 protein coding gene Chr14:36014696-36023243 (-)
C3H/HeJ ENSMUSGG00175054785
 protein coding gene Chr14:36050055-36075171 (-)
C57BL/6NJ ENSMUSGG00215055788
 protein coding gene Chr14:34761213-34786329 (-)
C57BL/6NJ ENSMUSG00215031559
 protein coding gene Chr14:34725854-34734402 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019153
 protein coding gene Chr14:37349842-37420789 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210031678
 protein coding gene Chr14:34660027-34668575 (-)
CBA/J ENSMUSGG00210054574
 protein coding gene Chr14:34695386-34720501 (-)
DBA/2J ENSMUSGG00185057827
 protein coding gene Chr14:39483211-39508407 (-)
DBA/2J ENSMUSG00185013441
 protein coding gene Chr14:39447891-39456438 (-)
FVB/NJ ENSMUSG00205021307
 protein coding gene Chr14:33879924-33888472 (-)
FVB/NJ ENSMUSGG00205054170
 protein coding gene Chr14:33915285-33940403 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055653
 protein coding gene Chr14:51753138-51778214 (-)
LP/J ENSMUSG00230016892
 protein coding gene Chr14:51717416-51725992 (-)
NOD/ShiLtJ ENSMUSG00190025197
 protein coding gene Chr14:34352072-34360619 (-)
NOD/ShiLtJ ENSMUSGG00190054717
 protein coding gene Chr14:34387430-34412546 (-)
NZO/HlLtJ ENSMUSGG00225055606
 protein coding gene Chr14:41990553-42015737 (-)
NZO/HlLtJ ENSMUSG00225050548
 protein coding gene Chr14:41955211-41963749 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010002898
 protein coding gene Chr14:37275532-37344558 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FERMT2, FERM domain containing kindlin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FERMT2, FERM domain containing kindlin 2
  • Synonyms
    KIND2, mig-2, MIG2, PLEKHC1, UNC112, UNC112B
  • Links
    NCBI Gene ID: 10979
    UniProt: Q96AC1

  • Chr Location
    14q22.1; chr14:52857267-52952435 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 4 alleles in 6 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice are embryonic lethal at or before E7.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    116
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    54
  • cDNA Data
    154
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037712 Ensembl Gene Model | MGI Sequence Detail 71324 C57BL/6J ±  kb
    transcript ENSMUST00000045905 Ensembl | MGI Sequence Detail 3293 Not Applicable  
    polypeptide ENSMUSP00000044554 Ensembl | MGI Sequence Detail 680 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      cDNA 155
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2145587
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 8
      Gene Ontology 12
      Phenotypes 42
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:389864 Murata K, et al., A novel miniTurbo knock-in mouse reveals a protein interaction network of USP46 in the brain. Exp Anim. 2026 Jan 1;75(1):63-72
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory