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Psat1 Gene Detail
Summary
  • Symbol
    Psat1
  • Name
    phosphoserine aminotransferase 1
  • Synonyms
    D8Ertd814e, EPIP, PSA
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183441
    NCBI Gene: 107272
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:15882487-15902423 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 10.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183441
 protein coding gene Chr19:15882042-15924701 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024956
 protein coding gene Chr19:13603466-13648919 (-)
A/J MGP_AJ_G0024933
 protein coding gene Chr19:12810393-12856961 (-)
AKR/J MGP_AKRJ_G0024903
 protein coding gene Chr19:13348662-13397423 (-)
BALB/cJ MGP_BALBcJ_G0024932
 protein coding gene Chr19:12855123-12899160 (-)
C3H/HeJ MGP_C3HHeJ_G0024690
 protein coding gene Chr19:13291118-13337212 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025374
 protein coding gene Chr19:14169427-14211761 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022793
 protein coding gene Chr19:13277988-13320014 (-)
CAST/EiJ MGP_CASTEiJ_G0024158
 protein coding gene Chr19:12862685-12908691 (-)
CBA/J MGP_CBAJ_G0024668
 protein coding gene Chr19:14573217-14624246 (-)
DBA/2J MGP_DBA2J_G0024800
 protein coding gene Chr19:12861598-12904329 (-)
FVB/NJ MGP_FVBNJ_G0024761
 protein coding gene Chr19:12787197-12833229 (-)
LP/J MGP_LPJ_G0024884
 protein coding gene Chr19:13604345-13646742 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024788
 protein coding gene Chr19:14540109-14589214 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025429
 protein coding gene Chr19:13264737-13311752 (-)
PWK/PhJ MGP_PWKPhJ_G0023907
 protein coding gene Chr19:12397441-12438417 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023712
 protein coding gene Chr19:12550068-12601865 (-)
WSB/EiJ MGP_WSBEiJ_G0024226
 protein coding gene Chr19:13284859-13330309 (-)



Homology
more
  • Human Ortholog
    PSAT1, phosphoserine aminotransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSAT1, phosphoserine aminotransferase 1
  • Synonyms
    EPIP, NLS2, PSA, PSAT, PSATD
  • Links
    NCBI Gene ID: 29968
    neXtProt AC: NX_Q9Y617
    UniProt: Q9Y617

  • Chr Location
    9q21.2; chr9:78297125-78330093 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PSAT1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit craniofacial defects, exencephaly and growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    918
  • Tissues
    116
  • cDNA Data
    28
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107272 NCBI Gene Model | MGI Sequence Detail 19937 C57BL/6J ±  kb
    transcript NM_001205339 RefSeq | MGI Sequence Detail 2295 ZRU/MplStud  
    polypeptide Q99K85 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013339 phosphoserine aminotransferase
      (term hierarchy)
    • EC
      2.6.1.52
    • InterPro Domains
      IPR000192 Aminotransferase class V domain
      IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site
      IPR022278 Phosphoserine aminotransferase
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 28
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1289292, MGI:2147628, MGI:2147656, MGI:3034454
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 13
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:344223 Zhang W, et al., NLRP14 deficiency causes female infertility with oocyte maturation defects and early embryonic arrest by impairing cytoplasmic UHRF1 abundance. Cell Rep. 2023 Dec 26;42(12):113531
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory