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Mill2 Gene Detail
Summary
  • Symbol
    Mill2
  • Name
    MHC I like leukocyte 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179989
    NCBI Gene: 243864
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:18573891-18599327 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1008 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179989
 protein coding gene Chr7:18573878-18603621 (+)
129S1/SvImJ ENSMUSG00200038639
 protein coding gene Chr7:11765334-11790454 (+)
A/J ENSMUSG00195052549
 protein coding gene Chr7:12212492-12237876 (+)
AKR/J ENSMUSG00220024440
 protein coding gene Chr7:10545474-10570838 (+)
BALB/cJ ENSMUSG00180051674
 protein coding gene Chr7:12068851-12094237 (+)
C3H/HeJ ENSMUSG00175048804
 protein coding gene Chr7:12647927-12673035 (+)
C57BL/6NJ ENSMUSG00215054701
 protein coding gene Chr7:11611634-11637105 (-)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005049790
 protein coding gene Chr7:12678479-12703842 (+)
CBA/J ENSMUSG00210051154
 protein coding gene Chr7:11874660-11899769 (+)
DBA/2J ENSMUSG00185053488
 protein coding gene Chr7:15321370-15346764 (+)
FVB/NJ ENSMUSG00205046643
 protein coding gene Chr7:12265835-12291193 (+)
JF1/MsJ ENSUMUG00000037294
 protein coding gene Chr7:18632327-18657438 (+)
LP/J ENSMUSG00230042410
 protein coding gene Chr7:19607117-19630883 (+)
NOD/ShiLtJ ENSMUSG00190048639
 protein coding gene Chr7:8527795-8553312 (+)
NZO/HlLtJ ENSMUSG00225053820
 protein coding gene Chr7:16899483-16924922 (+)
PWK/PhJ ENSLUMG00010037325
 protein coding gene Chr7:1479099-1504265 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005053326
 protein coding gene Chr7:19973709-19999196 (-)



Homology
more
  • Human Ortholog
    MICA, MHC class I polypeptide-related sequence A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MICA, MHC class I polypeptide-related sequence A
  • Synonyms
    MIC-A, PERB11.1
  • Links
    NCBI Gene ID: 100507436
    UniProt: Q29983

  • Chr Location
    chr6:31399784-31415315 (+)  GRCh38
  • Human Ortholog
    MICB, MHC class I polypeptide-related sequence B
  • Synonyms
    PERB11.2
  • Links
    NCBI Gene ID: 4277
    UniProt: Q29980

  • Chr Location
    6p21.33; chr6:31494881-31511124 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040987 Ensembl Gene Model | MGI Sequence Detail 25437 C57BL/6J ±  kb
transcript ENSMUST00000228493 Ensembl | MGI Sequence Detail 2043 Not Applicable  
polypeptide ENSMUSP00000154268 Ensembl | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • PDB
    6A97
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
  • GlyGen
    Q8HWE5 3 sites, 1 N-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
References
more
  • Summaries
    All 24
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:79325 Kasahara M, et al., A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13687-92
  • Latest
    J:268516 Kajikawa M, et al., Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility. Nat Commun. 2018 Oct 18;9(1):4330
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory